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Deoxynivalenol as potential modulator of human steroidogenesis
Kinga Anna Urbanek1, Dominika Ewa Habrowska-Górczyńska1, Karolina Kowalska1
1Laboratory of Cell Cultures and Genomic Analysis, Department of Comparative Endocrinology, Medical University of Lodz, Poland.
Abstract:
Deoxynivalenol (DON) is a type B trichothecene, produced by the Fusarium species. Exposure to DON might cause disruptive effects such as reduced weight gain, neuroendocrine changes and immune modulation in animals (rats, dogs, pigs). There is huge concern that similar effects can be observed in humans. DON is a potential regulator of intracellular steroidogenesis. It is also possible that DON will be involved in the regulation of miRNAs connected with steroidogenesis. This review summarizes the latest knowledge about the influence of DON on steroidogenesis and human hormonal balance.
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