Influence of simvastatin on red blood cell line in porcine bone marrow
A Snarska1, S Gonkowski2, L Rytel1
1Department and Clinic of Internal Diseases University of Warmia and Mazury in Olsztyn, Oczapowskiego 13-14, 10-719 Olsztyn, Poland.
Abstract:
Simvastatin is a drug commonly used to reduce the cholesterol level. 32 clinically healthy female pigs with a bodyweight of 35-40 kg, kept in standard laboratory conditions were chosen for the experiment and divided into 2 groups (control and experimental) consisting of 16 animals. The experimental group received simvastatin orally at a dose of 40 mg (one tablet once a day) for 56 days, and at the same time the control group received placebo (empty gelatin capsules). Bone marrow smears and peripheral blood samples were evaluated. The obtained results indicate that simvastatin may inhibit erythropoiesis even after a relatively short period of administration, and observed changes can be the cause of some symptoms (for example anemia) occurring during statin therapy.
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