Related Experiment Video

Updated: Feb 12, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
09:29

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

19.0K

Experience with eribulin in triple-negative metastatic breast cancer: case studies

Maria Isabel Gallegos Sancho1, Raúl Márquez-Vázquez2, Alfonso Sánchez-Muñoz3

  • 1Medical Oncology Department, Complejo Asistencial De Segovia, Segovia, Spain.

Future Oncology (London, England)
|April 4, 2018
PubMed

Insights

Eribulin shows promise in treating advanced triple-negative breast cancer (TNBC) that has spread to the brain. This chemotherapy offers a valuable option for patients with limited treatment alternatives.

Area of Science:

  • Oncology
  • Medical research

Background:

  • Triple-negative breast cancer (TNBC) lacks targeted therapies and has a poor prognosis.
  • Chemotherapy remains the primary treatment for TNBC.
  • Metastatic TNBC, especially with brain involvement, presents significant treatment challenges.

Observation:

  • Three distinct cases of patients with advanced TNBC are presented.
  • Case 1: Young woman with cerebral/cerebellar metastases responded to fourth-line eribulin.
  • Case 2: Metastatic patient refractory to capecitabine + bevacizumab achieved partial response with eribulin + bevacizumab.
  • Case 3: Heavily pre-treated patient showed improved progression-free interval with third-line eribulin.

Findings:

  • Eribulin demonstrated efficacy in heavily pre-treated and metastatic TNBC patients.
  • Objective responses and improved progression-free intervals were observed.
  • Combination therapy with bevacizumab showed potential benefit.

Implications:

  • Eribulin may be a viable treatment option for refractory or advanced TNBC.
  • Further investigation into eribulin's role in TNBC, including brain metastases, is warranted.
  • These findings support exploring novel therapeutic strategies for poor-prognosis breast cancer subtypes.
Keywords:
chemoresistanceeribulintriple-negative breast cancer

More Related Videos

Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior09:44

Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior

Published on: June 13, 2016

8.9K
Generating a Murine Orthotopic Metastatic Breast Cancer Model and Performing Murine Radical Mastectomy05:05

Generating a Murine Orthotopic Metastatic Breast Cancer Model and Performing Murine Radical Mastectomy

Published on: November 29, 2018

11.7K

Related Concept Videos

Scalar and Vector Triple Products01:06

Scalar and Vector Triple Products

Two vectors can be multiplied using a scalar product or a vector product. The resultant of a scalar product is scalar, while with vector products, the resultant is a vector. These rules of the scalar or vector product between two vectors can be applied to multiple vectors to obtain meaningful combinations. The scalar triple product is the dot product of a vector with the cross product of two vectors.
The scalar triple product is the dot product of a vector with the cross product of two vectors....
4.5K
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.6K
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.6K
Positive, Negative, and Zero Work00:58

Positive, Negative, and Zero Work

Work is done on an object when energy is transferred to the object. In other words, work is done when a force acts on a body that undergoes a displacement from one position to another. By definition, the work done by a force is the integral of the force with respect to the displacement along its path. Forces can vary as a function of position, and displacements can occur along various paths between two points. The magnitude of a force multiplied by the cosine of the angle that the force makes...
22.3K
What is an Experiment?01:12

What is an Experiment?

An experiment is a planned activity carried out under controlled conditions. The purpose of an experiment is to investigate the relationship between two variables. When one variable causes change in another, we call the first variable the explanatory or independent variable. The affected variable is called the response or dependent variable. In a randomized experiment, the researcher manipulates values of the explanatory variable and measures the resulting changes in the response variable. The...
19.1K
The Stanford Prison Experiment03:20

The Stanford Prison Experiment

The famous and controversial Stanford Prison Experiment, conducted by social psychologist Philip Zimbardo and his colleagues at Stanford University, demonstrated the power of social roles, social norms, and scripts.
24.8K