Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hemodynamic hypertrophied left ventricular patterns in systemic hypertension.

G de Simone1, L Di Lorenzo, D Moccia

  • 1Cardiology Unit, Second Medical School, University of Naples, Italy.

The American Journal of Cardiology
|December 1, 1987
PubMed
Summary

Systemic hypertension leads to left ventricular (LV) hypertrophy, with eccentric hypertrophy being more common. LV contractile capacity may rely on increased muscle mass rather than enhanced inotropic state in hypertensive patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A study protocol for a randomised controlled trial evaluating the safety and efficiency of the YEARS algorithm versus computed tomography pulmonary angiography only for suspected acute pulmonary embolism in patients with cancer: the Hydra Study.

Thrombosis research·2026
Same author

Fructose and salt induce sex- and ovary dependent cardiac hypertrophy in Dahl salt-sensitive rats.

Frontiers in cardiovascular medicine·2026
Same author

Cross-linked carboxymethyl cellulose and silk proteins for dry eye disease management and corneal wound healing: in vivo and in vitro results.

European review for medical and pharmacological sciences·2026
Same author

Dissection of Nitric Oxide binding pathway in Nitrobindins reveals hidden structural details.

International journal of biological macromolecules·2025
Same author

The value of TECAR in acute painful osteoporotic vertebral fractures: a pilot study.

La Clinica terapeutica·2024
Same author

Rankl genetic deficiency and functional blockade undermine skeletal stem and progenitor cell differentiation.

Stem cell research & therapy·2024

Area of Science:

  • Cardiology
  • Physiology
  • Hypertension Research

Background:

  • Systemic hypertension frequently causes left ventricular (LV) hypertrophy.
  • Understanding the hemodynamic adaptations in hypertrophied LV is crucial for managing hypertensive heart disease.

Purpose of the Study:

  • To investigate the hemodynamic patterns of the hypertrophied left ventricle in untreated systemic hypertension.
  • To differentiate between concentric and eccentric LV hypertrophy adaptations to pressure overload.

Main Methods:

  • M-mode echocardiography was used to assess 42 untreated hypertensive patients and 45 normotensive controls.
  • Key hemodynamic parameters including cardiac dimensions, wall thickness, and contractility indices were measured.

Main Results:

Related Experiment Videos

  • Hypertensive patients exhibited increased cardiac dimensions, wall thickness, and cardiac output compared to controls.
  • Eccentric hypertrophy (74%) was associated with increased dimensions and LV contractility, while concentric hypertrophy (26%) showed normal dimensions but higher contractility.
  • Normalized stress/volume and systolic pressure/dimension ratios indicated preserved LV contractile function.

Conclusions:

  • Left ventricular hypertrophy in hypertension presents with distinct patterns of eccentric and concentric remodeling.
  • LV contractile capacity appears to be maintained by increased myocardial mass rather than an elevated inotropic state.