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Renal response to volume expansion in atrial-appendectomized dogs
B A Benjamin1, C H Metzler, T V Peterson
1Department of Medical Physiology, Texas A&M University, College of Medicine, College Station 77843.
The American Journal of Physiology
|November 1, 1987
Summary
Chronic removal of atrial appendages (ATX) in dogs did not alter renal responses to volume expansion (VE). Atrial appendectomy also failed to reduce the increase in atrial natriuretic factor (ANF) after VE.
Area of Science:
- Physiology
- Renal Physiology
- Cardiovascular Physiology
Background:
- The atrial appendages are a potential source of atrial natriuretic factor (ANF).
- The role of atrial appendages in regulating renal response to volume expansion is not fully understood.
Purpose of the Study:
- To investigate the effect of chronic bilateral atrial appendectomy (ATX) on the renal response to volume expansion (VE) in dogs.
- To determine if ATX alters the release of ANF during VE.
- To assess the role of vagal pathways in mediating these responses.
Main Methods:
- Chronic bilateral ATX or sham surgery in anesthetized dogs.
- Volume expansion (VE) protocol.
- Measurement of urine flow, sodium excretion, and plasma ANF levels.
- Vagotomy performed in a second study phase.
Main Results:
- VE induced equivalent diuresis, natriuresis, and increased fractional sodium excretion in both ATX and sham groups.
- VE caused similar increases in central venous and mean arterial pressures in both groups.
- ATX did not attenuate the increase in plasma ANF levels following VE.
- Vagotomy did not alter the renal response to VE or the ANF response to VE.
Conclusions:
- Chronic bilateral ATX in dogs does not affect the renal response to volume expansion.
- Atrial appendectomy does not attenuate the increase in ANF following volume expansion.
- Vagal pathways are not essential for ANF release during VE and do not unmask effects of ATX on renal function.