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Related Experiment Videos

Bone and plasma calcium homeostasis.

A M Parfitt1

  • 1Henry Ford Hospital, Bone and Mineral Research Laboratory, Detroit, MI 48202.

Bone
|January 1, 1987
PubMed
Summary
This summary is machine-generated.

Plasma calcium regulation involves a set point with daily oscillations, influenced by genetics. Bone surfaces play a key role in maintaining calcium balance, even without parathyroid hormone or calcitonin.

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Area of Science:

  • Physiology
  • Endocrinology
  • Bone Biology

Background:

  • Plasma free calcium concentration is tightly regulated within narrow limits.
  • This regulation exhibits individual set points, circadian oscillations, and genetic influences.
  • Calcium homeostasis is crucial for numerous physiological processes.

Purpose of the Study:

  • To elucidate the key features of plasma free calcium concentration regulation.
  • To propose a model explaining calcium homeostasis mechanisms.
  • To investigate the role of bone surfaces in calcium balance.

Main Methods:

  • Analysis of plasma calcium regulation features, including set points and oscillations.
  • Experimental induction of hyper- and hypocalcemia to study error correction.

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  • Autoradiography to demonstrate calcium exchange across bone surfaces.
  • Investigation of the role of vitamin D, parathyroid hormone, and calcitonin.

    • Main Results:

    • Plasma calcium levels show a set point with standard deviation and an intrinsic circadian rhythm.
    • Error correction in calcium levels is slow, typically taking over 12 hours.
    • Calcium homeostasis can function without parathyroid hormone or calcitonin if vitamin D is present.
    • The quiescent bone surface is identified as the primary site for calcium homeostasis.

    Conclusions:

    • Calcium homeostasis is best explained by a system located at the quiescent bone surface.
    • Both homeostatic and remodeling bone systems contribute to calcium balance.
    • Vitamin D is essential for efficient calcium correction, even in the absence of other key hormones.