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Related Experiment Video

Updated: Feb 12, 2026

Generation and Quantitative Analysis of Pulsed Low Frequency Ultrasound to Determine the Sonic Sensitivity of Untreated and Treated Neoplastic Cells

Generation and Quantitative Analysis of Pulsed Low Frequency Ultrasound to Determine the Sonic Sensitivity of Untreated and Treated Neoplastic Cells

Published on: July 22, 2015

Neoplastic Myelopathies.

Jing Wu, Surabhi Ranjan

Continuum (Minneapolis, Minn.)

|April 4, 2018

Summary

This summary is machine-generated.

Neoplastic myelopathies, including spinal cord tumors and treatment-related disorders, are uncommon but serious. Prompt diagnosis and management of these spinal cord neoplasms are crucial for preventing severe neurological damage.

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Area of Science:

Neurology
Oncology
Spinal Cord Disorders

Background:

Neoplastic myelopathies are uncommon neurologic disorders causing significant morbidity.
Primary spinal cord tumors are classified as intramedullary, intradural extramedullary, or extradural.
Metastatic tumors are the most common spinal tumors, and extradural metastatic spinal cord compression is a neurologic emergency.

Purpose of the Study:

To discuss the diagnosis and management of spinal cord neoplasms.
To review spinal cord disorders resulting from cancer treatments.
To emphasize the importance of early diagnosis and treatment for preventing neurological sequelae.

Main Methods:

Review of primary spinal cord tumor classifications (intramedullary, intradural extramedullary, extradural).
Discussion of common intramedullary tumors like diffuse gliomas and ependymal tumors, including their molecular characteristics (e.g., IDH-mutant, 1p/19q codeletion, NF2 mutations).
Analysis of metastatic spinal tumors and the emergent nature of extradural metastatic spinal cord compression.

Main Results:

Diffuse gliomas (astrocytomas, oligodendrogliomas, glioblastomas) and ependymomas are common intramedullary tumors with distinct molecular profiles.
Ependymomas show nine distinct molecular subgroups, with NF2 mutations frequent in spinal cord ependymomas.
Metastatic tumors are the most common spinal neoplasms, and prompt diagnosis of extradural metastatic spinal cord compression is critical for patient outcomes.

Conclusions:

Neoplastic myelopathies encompass a range of conditions, from primary spinal tumors to paraneoplastic syndromes.
Understanding the clinical features and management of neoplastic myelopathies is essential for neurologists.
Early diagnosis and treatment of spinal cord neoplasms and treatment-related disorders can prevent devastating neurologic sequelae.