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Non-invasive endoscopic technique to assess gastrointestinal perfusion
P I Allen1, D Gourevitch, M Goldman
1East Birmingham Hospital, UK.
The British Journal of Surgery
|November 1, 1987
Summary
Endoscopic laser Doppler (LD) provides a non-invasive method to assess colonic mucosal blood flow. This technique accurately reflects changes in microcirculatory flux and oxygen tension, aiding gastrointestinal disorder diagnosis.
Area of Science:
- Gastroenterology
- Biomedical Engineering
- Physiology
Background:
- Assessing mucosal blood flow in gastrointestinal disorders is crucial but challenging without non-invasive in vivo techniques.
- Existing methods for evaluating colonic microcirculation are limited.
Purpose of the Study:
- To compare endoscopic laser Doppler (LD) with oxygen electrode (OE) measurements for assessing colonic mucosal blood flow.
- To validate LD as a reliable tool for measuring microcirculatory flux in the colon.
Main Methods:
- An isolated dog colon preparation was used with variable perfusion controlled by an electromagnetic flow probe.
- Endoscopic laser Doppler (LD) and oxygen electrode (OE) measurements were taken at mucosal and serosal sites.
- Data were analyzed for correlations between LD, OE, and electromagnetic flow measurements.
Main Results:
- Laser Doppler (LD) measurements showed a progressive trend of increasing flux from the cecum to the rectum, both at mucosal and serosal levels.
- Serosal LD values significantly correlated with electromagnetic flow (r = 0.544).
- Oxygen electrode (OE) measurements also showed a significant linear correlation with electromagnetic flow (r = 0.65) and microcirculatory flux (r = 0.441).
Conclusions:
- Endoscopic laser Doppler (LD) is an accurate and non-invasive method for assessing colonic microcirculation.
- LD measurements reliably reflect changes in mucosal blood flow and correlate with oxygen tension.
- This technique holds promise for diagnosing and monitoring gastrointestinal disorders.