Related Experiment Video

Updated: Feb 12, 2026

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

1.7K

Prevalence of Hypersensitivity Reactions in Children Associated with Acetaminophen: A Systematic Review and

Sofianne Gabrielli, Alexandra Langlois, Moshe Ben-Shoshan

    International Archives of Allergy and Immunology
    |April 4, 2018
    PubMed

    Insights

    Hypersensitivity reactions to acetaminophen, a common fever reducer, occur in over 25% of cases. In children with suspected allergy, acetaminophen hypersensitivity prevalence was 10.1% via oral challenge.

    Area of Science:

    • Pediatric Allergy and Immunology
    • Pharmacovigilance
    • Drug Hypersensitivity

    Background:

    • Acetaminophen is a widely used antipyretic in pediatric populations.
    • Limited data exist regarding hypersensitivity reactions to acetaminophen.

    Observation:

    • A systematic review of 85 studies (1,030 participants) characterized acetaminophen reactions.
    • Immediate reactions occurred in >25%, nonimmediate cutaneous reactions in ~25%.
    • Severe reactions like SJS/TEN and fixed drug eruptions were also reported.

    Findings:

    • A meta-analysis of 5 pediatric studies found a 10.1% prevalence of acetaminophen hypersensitivity in children undergoing oral challenge.
    • This highlights a significant, though not fully quantified, risk in this population.

    Implications:

    • Further research is needed to assess immediate and nonimmediate acetaminophen hypersensitivity risks.
    • Elucidating the mechanisms of acetaminophen hypersensitivity is crucial for improved patient safety.
    Abstract

    Keywords:
    AcetaminophenAllergyHypersensitivityParacetamolPediatrics

    More Related Videos

    Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment08:36

    Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

    Published on: April 19, 2024

    1.2K
    Oral Biofilm Sampling for Microbiome Analysis in Healthy Children10:42

    Oral Biofilm Sampling for Microbiome Analysis in Healthy Children

    Published on: December 31, 2017

    17.9K

    Related Concept Videos

    Prevalence and Incidence01:08

    Prevalence and Incidence

    In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
    Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
    1.9K
    Hypersensitivities01:30

    Hypersensitivities

    Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
    Types of Hypersensitivities
    Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
    7.7K
    Allergic Reactions02:06

    Allergic Reactions

    Overview
    32.4K
    Review and Preview01:10

    Review and Preview

    In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
    Percentiles are a type of fractile that partition data into...
    8.4K
    Review and Preview01:13

    Review and Preview

    Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
    11.6K
    Random and Systematic Errors01:20

    Random and Systematic Errors

    Scientists always try their best to record measurements with the utmost accuracy and precision. However, sometimes errors do occur. These errors can be random or systematic. Random errors are observed due to the inconsistency or fluctuation in the measurement process, or variations in the quantity itself that is being measured. Such errors fluctuate from being greater than or less than the true value in repeated measurements. Consider a scientist measuring the length of an earthworm using a...
    15.3K