Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Visual Processing during Short-Term Memory Binding in Mild Alzheimer's Disease.

Gerardo Fernández1, David Orozco2, Osvaldo Agamennoni1

  • 1Universidad Nacional del Sur (UNS), Bahía Blanca, Argentina, Instituto de Investigaciones en Ingeniería Eléctrica (IIIE) (UNS-CONICET), Bahía Blanca, Buenos Aires, Argentina.

Journal of Alzheimer'S Disease : JAD
|April 5, 2018
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Source-space EEG alpha activity reveals brain age gaps due to neurodegeneration and disparity.

Communications biology·2026
Same author

Eye movement analysis during working memory tasks correlates with cognitive, clinical, and anatomical metrics in multiple sclerosis.

Multiple sclerosis journal - experimental, translational and clinical·2026
Same author

Commonalities and Divergences in the Cognitive Profiles of Autism and Dementia: Protocol for a Narrative Literature Review.

JMIR research protocols·2026
Same author

Diversity-sensitive brain clocks linked to biophysical mechanisms in aging and dementia.

Nature. Mental health·2026
Same author

The exposome of brain aging across 34 countries.

Nature medicine·2026
Same author

Blood-based AT(N) biomarkers for Alzheimer's disease and frontotemporal lobar degeneration in Latin America.

Nature aging·2026
Same journal

Diluting the signal: Class-level pooling and the ecological fallacy in meta-analyses of anti-amyloid monoclonal antibodies.

Journal of Alzheimer's disease : JAD·2026
Same journal

Gut microbiota alterations in Alzheimer's disease and mild cognitive impairment: A systematic review and meta-analysis.

Journal of Alzheimer's disease : JAD·2026
Same journal

Stage-dependent relationship between sleep duration and cortical tau deposition in cognitively impaired individuals: A cross-sectional study.

Journal of Alzheimer's disease : JAD·2026
Same journal

Multilayer brain connectivity and long-term cognitive changes in individuals at risk for Alzheimer's disease.

Journal of Alzheimer's disease : JAD·2026
Same journal

The creation and verification of a detection model for mild cognitive impairment by employing eye-tracking and gait metrics.

Journal of Alzheimer's disease : JAD·2026
Same journal

Compartment-specific analysis reveals disrupted astrocytic calcium transients in anesthetized Alzheimer's disease mice.

Journal of Alzheimer's disease : JAD·2026
See all related articles
This summary is machine-generated.

Alzheimer's disease patients show impaired eye movements during memory tasks, specifically when binding visual information. This links oculomotor and cognitive deficits in Alzheimer's disease.

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Cognitive Psychology

Background:

  • Alzheimer's disease (AD) is characterized by attentional and oculomotor abnormalities affecting cognition.
  • Eye movement analysis is increasingly used to understand AD pathophysiology.
  • The link between eye movement abnormalities and cognitive deficits in AD, particularly in memory tasks, requires further investigation.

Purpose of the Study:

  • To investigate the relationship between eye movement fixation behaviors and performance on a visual short-term memory binding task in patients with mild Alzheimer's disease.
  • To explore how Alzheimer's disease affects the processing of bound versus unbound visual features during memory encoding.

Main Methods:

  • Analyzed eye movement fixation behaviors in 13 healthy older adults (Controls) and 13 patients with probable mild AD.
Keywords:
Alzheimer’s diseaseVisual short-term memory bindingeye movementsgazingvisual processing

Related Experiment Videos

  • Participants performed a visual short-term memory binding task involving detecting changes in bicolored objects.
  • Compared eye movements during the encoding of 'Unbound Colors' (features remembered separately) and 'Bound Colors' (features integrated within objects).

    • Main Results:

    • Patients with mild AD exhibited selective memory binding impairments, consistent with known AD patterns.
    • Significant eye movement impairments were observed in AD patients exclusively when processing Bound Colors.
    • AD patients demonstrated a notable decrease in mean gaze duration during the encoding of color-color bindings.

    Conclusions:

    • Eye movement abnormalities in Alzheimer's disease are specifically linked to difficulties in binding visual information.
    • Findings highlight a connection between oculomotor and cognitive deficits in AD, offering insights into memory impairments.
    • This research opens avenues for exploring AD's pathophysiological mechanisms and developing biomarkers for oculomotor and cognitive disorders.