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A Specific Melon Concentrate Exhibits Photoprotective Effects from Antioxidant Activity in Healthy Adults

Laure Egoumenides1, Audrey Gauthier2, Sandy Barial3

  • 1Bionov Research, 34090 Montpellier, France. laure.egoumenides@bionov.fr.

Nutrients
|April 5, 2018
PubMed

Insights

Melon concentrate, taken orally or applied topically, enhances skin protection against UV damage. This antioxidant-rich supplement boosts the skin's natural defenses, reducing sunburn and improving overall skin health.

Area of Science:

  • Dermatology and Cosmetology
  • Nutraceuticals and Food Science
  • Biochemistry and Molecular Biology

Background:

  • The skin serves as the primary defense against external aggressors, with ultraviolet (UV) radiation posing significant risks.
  • UV exposure can lead to sunburn, photoaging, immune suppression, and skin cancer, necessitating protective strategies.
  • Antioxidants are recognized for their potential to mitigate UV-induced skin damage and its associated health concerns.

Purpose of the Study:

  • To evaluate the photoprotective potential of melon concentrate through both dietary supplementation and topical application.
  • To investigate the effects of melon concentrate on key indicators of UV-induced skin damage and the skin's antioxidant capacity.

Main Methods:

  • A clinical study was conducted to assess photoprotection by measuring the Minimal Erythema Dose (MED) following melon concentrate administration.
  • An in vitro study utilized human skin explants to analyze the impact of melon concentrate on sunburn cell formation, endogenous antioxidant enzymes, and melanin levels.
  • Both oral and topical administration of melon concentrate, individually and in combination, were investigated.

Main Results:

  • Clinical findings indicated that melon concentrate administration (oral and/or topical) significantly increased the Minimal Erythema Dose (MED).
  • In vitro studies showed that melon concentrate boosted endogenous antioxidant enzymes and reduced the formation of sunburn cells in irradiated skin explants.
  • Melon concentrate also demonstrated a reduction in melanin levels in UV-exposed skin explants.

Conclusions:

  • Melon concentrate exhibits significant photoprotective properties, attributed to its potent antioxidant capabilities.
  • Both oral and topical administration of melon concentrate can serve as effective strategies to protect the skin from UV-induced damage.
  • Further research into melon concentrate as a photoprotective agent is warranted.
Keywords:
melaninminimal erythema doseoxidative stresssunburn cellssuperoxide dismutaseultraviolet radiation

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