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Updated: Feb 12, 2026

In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model
Published on: January 21, 2018
Theme trends and knowledge structure on choroidal neovascularization: a quantitative and co-word analysis
Fangkun Zhao1,2,3, Bei Shi4, Ruixin Liu1,5
1Department of Ophthalmology, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
This study mapped choroidal neovascularization (CNV) research trends using bibliometric analysis. It identified well-developed areas like clinical drug therapy and highlighted under-researched topics for future investigation.
Area of Science:
- Ophthalmology
- Bibliometrics
- Medical Research Analysis
Background:
- Choroidal neovascularization (CNV) research landscape requires comprehensive analysis.
- Understanding knowledge structure and distribution patterns is crucial for advancing CNV studies.
Purpose of the Study:
- To survey the distribution pattern and knowledge structure of choroidal neovascularization (CNV) research.
- To identify research hotspots and emerging trends in CNV literature.
Main Methods:
- Bibliometric analysis of 2366 CNV papers published from 2012 to 2017.
- Quantitative analysis of MeSH terms using BICOMB and hierarchical cluster analysis.
- Social network analysis (SNA) to map research collaborations and identify central components.
Main Results:
- Identified 44 high-frequency MeSH terms clustered into 6 main research categories.
- Clinical drug therapy, pathology, and diagnosis of CNV are well-developed research areas.
- Metabolism, etiology, genetics, and animal model research for CNV are relatively immature, indicating future research opportunities.
Conclusions:
- CNV research exhibits a divergent pattern with 6 identifiable research categories.
- This bibliometric study provides insights into publication trends and guides future research directions in CNV.
- Researchers can leverage these findings to identify new project opportunities and focus areas.
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