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Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
Published on: September 26, 2018
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CD6 expression has no effect on atherosclerosis in apolipoprotein E-deficient mice
Juying Han1, Gospel Enyindah-Asonye2, Feng Lin3
1Department of Cellular & Molecular Medicine, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, USA.
BMC Research Notes
|April 5, 2018
Summary
Deficiency of CD6, a lymphocyte protein, did not increase atherosclerosis in mice lacking ApoE, regardless of diet. This suggests CD6 does not impact atherosclerosis development in this model.
Area of Science:
- Immunology
- Cardiovascular Science
- Atherosclerosis Research
Background:
- CD6 is a cell surface protein on lymphocytes.
- CD6 influences natural antibody production.
- Atherosclerosis is a complex cardiovascular disease.
Purpose of the Study:
- To investigate if CD6 deficiency exacerbates atherosclerosis in ApoE-deficient mice.
- To assess the impact of CD6 on immune responses and atherosclerosis under different dietary conditions.
Main Methods:
- Comparison of ApoE-deficient and CD6/ApoE double-deficient mice.
- Analysis of cholesterol levels, IgM, B1a cells, and aortic root lesion areas.
- Evaluation across chow and western-type diets, considering sex differences.
Main Results:
- Western-type diet increased cholesterol and lesion areas but decreased B1a cells.
- Sex influenced body weight, HDL cholesterol, B1a cells, and lesion size on chow diet.
- CD6 deficiency did not alter atherosclerosis development in mice on either diet.
Conclusions:
- Loss of CD6 did not reduce B1a cells or protective IgM levels as hypothesized.
- CD6 deficiency does not impact atherosclerosis progression in ApoE-deficient mice.
- Diet and sex are significant factors in atherosclerosis, but CD6 is not a key player in this model.
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