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Interleukin-10 as a novel biomarker of metabolic risk factors

Himani Kulshrestha1, Vani Gupta1, Sameeksha Mishra1

  • 1Department of Physiology, King George's Medical University, Lucknow, India.

Diabetes & Metabolic Syndrome
|April 5, 2018
PubMed

Insights

Lower levels of Interleukin-10 (IL-10), an adipocytokine from visceral fat, correlate with more metabolic risk factors in children. This suggests IL-10 may indicate metabolic health status.

Area of Science:

  • Endocrinology
  • Metabolic Syndrome Research
  • Adipocytokine Signaling

Background:

  • Interleukin-10 (IL-10) is an adipocytokine predominantly found in visceral fat.
  • Its role in metabolic health requires further investigation.

Purpose of the Study:

  • To examine the association between circulating Interleukin-10 levels and the number of metabolic risk factors in children.
  • To determine if IL-10 can serve as a biomarker for metabolic disorders.

Main Methods:

  • Plasma IL-10 levels were quantified using enzyme-linked immunosorbent assay (ELISA).
  • Participants were stratified into four groups based on IL-10 concentrations.
  • Metabolic risk factors included waist circumference, BMI, dyslipidemia, hypertension, and glucose intolerance.

Main Results:

  • A significant inverse correlation was observed between plasma IL-10 levels and the mean number of metabolic risk factors.
  • Reduced IL-10 levels were associated with an increased prevalence of obesity, dyslipidemia, high blood pressure, and glucose intolerance.

Conclusions:

  • Circulating IL-10 levels demonstrate a negative correlation with the multiplicity of metabolic risk factors.
  • IL-10 may function as a valuable biomarker for identifying children at risk of metabolic disorders.
Abstract

Keywords:
BiomarkersInterleukin-10Metabolic disordersObesityRisk factors

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