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Is there a relationship between resistin levels and left ventricular end-diastolic pressure?

Özge Turgay Yıldırım1, Aylin Yıldırır, Leyla Elif Sade

  • 1Department of Cardiology, Faculty of Medicine, Başkent University; Ankara-Turkey. ozgeturgay@gmail.com.

Anatolian Journal of Cardiology
|April 5, 2018
PubMed

Insights

This study found no correlation between resistin levels and left ventricular end-diastolic pressure (LVEDP) or coronary artery disease (CAD) severity. Resistin

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Biomarkers

Background:

  • Resistin, a peptide hormone, is linked to atherosclerosis and diabetes.
  • Elevated resistin levels correlate with coronary artery disease (CAD) and heart failure severity.
  • A potential association between resistin and left ventricular end-diastolic pressure (LVEDP) is hypothesized but not yet studied.

Purpose of the Study:

  • To investigate the relationship between resistin levels and LVEDP in patients with suspected CAD.
  • To evaluate the association of resistin with CAD severity, carotid intima-media thickness (CIMT), and echocardiographic diastolic dysfunction.

Main Methods:

  • 128 euvolemic patients with suspected CAD were enrolled.
  • Resistin levels were measured using ELISA.
  • LVEDP, CAD severity (≥50% stenosis), CIMT, and diastolic dysfunction parameters were assessed.

Main Results:

  • No significant difference in LVEDP or resistin levels was observed between patients with and without severe CAD.
  • Resistin levels showed no correlation with LVEDP, ejection fraction, Gensini score, or CIMT.
  • No significant correlation was found between resistin levels and echocardiographic diastolic dysfunction parameters.

Conclusions:

  • Resistin levels are not significantly correlated with LVEDP, CAD severity, CIMT, or diastolic dysfunction.
  • Further research is needed to clarify the clinical utility of resistin as a biomarker.
Abstract

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