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Updated: Oct 14, 2026

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In Vivo Modeling of the Morbid Human Genome using Danio rerio
Published on: August 24, 2013
Modeling Alzheimer's and Other Age Related Human Diseases in Embryonic Systems
Chu Hsien Lim1, Ajay S Mathuru2,3
1Yale NUS College, 16 College Avenue West, Singapore 138610, Singapore. limchuhsien@yale-nus.edu.sg.
Journal of Developmental Biology
|April 5, 2018
Abstract:
Modeling human disease in animals is an important strategy to discover potential methods of intervention. We suggest that there is much to be gained by employing a multi-model approach that takes advantage of different animal systems used in the laboratory simultaneously. We use the example of modeling Alzheimer's disease in Drosophila melanogaster, Caenorhabditis elegans, and Danio rerio to illustrate how such an approach can be employed to investigate the pathophysiology of the disease.

