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Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
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Canonical Sonic Hedgehog Signaling in Early Lung Development
Hugo Fernandes-Silva1,2, Jorge Correia-Pinto3,4,5, Rute Silva Moura6,7,8
1Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710‑057 Braga, Portugal. hugosilva@med.uminho.pt.
Journal of Developmental Biology
|April 5, 2018
Summary
Sonic Hedgehog (SHH) is crucial for embryonic development, regulating cell growth and tissue formation. This review details SHH
Area of Science:
- Developmental Biology
- Molecular Biology
- Cell Signaling
Background:
- The canonical hedgehog (HH) signaling pathway is vital for embryonic development, controlling cell growth, differentiation, migration, and tissue polarity.
- Sonic Hedgehog (SHH), a key HH protein, is essential for lung development, with abnormal levels causing foregut defects and lung hypoplasia.
Purpose of the Study:
- To review the critical role of Sonic Hedgehog (SHH) in the early stages of lung development.
- To examine SHH's involvement in lung specification, primary bud formation, and branching morphogenesis.
Main Methods:
- Literature review of studies on Sonic Hedgehog (SHH) signaling in embryonic lung development.
- Analysis of molecular interactions between SHH and other signaling pathways influencing pulmonary morphogenesis.
Main Results:
- Sonic Hedgehog (SHH) acts as a key morphogen, initiating and guiding lung development processes.
- SHH signaling, involving receptors like Patched1 and Smoothened and transcription factors like GLI, is fundamental for pulmonary morphogenesis.
Conclusions:
- Sonic Hedgehog (SHH) signaling is indispensable for normal lung development, from initial specification to complex branching.
- Understanding SHH's molecular mechanisms and interactions is crucial for addressing lung developmental defects.
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