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Updated: Feb 12, 2026

Mouse Genome Engineering Using Designer Nucleases
Published on: April 2, 2014
Engineering the Drosophila Genome for Developmental Biology
Dagmara Korona1, Stefan A Koestler2, Steven Russell3
1Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK. dk500@cam.ac.uk.
Abstract:
The recent development of transposon and CRISPR-Cas9-based tools for manipulating the fly genome in vivo promises tremendous progress in our ability to study developmental processes. Tools for introducing tags into genes at their endogenous genomic loci facilitate imaging or biochemistry approaches at the cellular or subcellular levels. Similarly, the ability to make specific alterations to the genome sequence allows much more precise genetic control to address questions of gene function.
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