Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Key Techniques in Microbiology01:19

Key Techniques in Microbiology

2.5K
Aseptic techniques prevent contamination, ensure experimental accuracy, and protect researchers and microbial cultures. These techniques are essential in clinical, industrial, and research settings where sterility is required.Maintaining Sterility in Laboratory PracticesScientists maintain sterility by sterilizing tools with heat or chemicals, disinfecting work surfaces, and handling cultures in controlled environments. Working near an open flame or within a laminar flow hood reduces the risk...
2.5K
Key Elements for Plant Nutrition02:35

Key Elements for Plant Nutrition

24.4K
Like all living organisms, plants require organic and inorganic nutrients to survive, reproduce, grow and maintain homeostasis. To identify nutrients that are essential for plant functioning, researchers have leveraged a technique called hydroponics. In hydroponic culture systems, plants are grown—without soil—in water-based solutions containing nutrients. At least 17 nutrients have been identified as essential elements required by plants. Plants acquire these elements from the...
24.4K
Sustainable Development01:43

Sustainable Development

15.2K
As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
15.2K
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.2K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.2K
Language Development01:22

Language Development

936
Children master language quickly and with relative ease, supported by both biological predisposition and reinforcement. B. F. Skinner (1957) proposed that language is learned through reinforcement, while Noam Chomsky (1965) argued that language acquisition mechanisms are biologically determined.
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
936
Development of the Lymphatic System01:15

Development of the Lymphatic System

2.2K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Postnatal relevance of HOXA5 transcription factor in cerebellum-associated behaviors and disorders.

Behavioral and brain functions : BBF·2026
Same author

HOXA5-driven transcriptional program in lung development.

Developmental biology·2025
Same author

A sustained Hox program delineates brainstem neurons essential for breathing.

bioRxiv : the preprint server for biology·2025
Same author

Loss of Hoxa5 function affects Hox gene expression in different biological contexts.

Scientific reports·2024
Same author

Multimodal Hox5 activity generates motor neuron diversity.

Communications biology·2024
Same author

Multimodal Hox5 activity generates motor neuron diversity.

bioRxiv : the preprint server for biology·2024

Related Experiment Video

Updated: Feb 12, 2026

Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches
08:25

Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches

Published on: November 21, 2018

14.3K

Hoxa5: A Key Player in Development and Disease.

Lucie Jeannotte1,2, Florian Gotti3,4, Kim Landry-Truchon5,6

  • 1Centre de recherche sur le cancer de l'Université Laval; CRCHU de Québec, L'Hôtel-Dieu de Québec, QC G1R 3S3, Canada. lucie.jeannotte@crhdq.ulaval.ca.

Journal of Developmental Biology
|April 5, 2018
PubMed
Summary

The Homeobox A5 (Hoxa5) gene is essential for embryonic development, particularly lung organogenesis and skeletal patterning. Its dysregulation is linked to developmental defects and cancer predisposition.

Keywords:
Hox genesgene regulationlong non-coding RNAorganogenesistumorigenesis

More Related Videos

Biomechanical Analysis Methods to Assess Professional Badminton Players' Lunge Performance
06:36

Biomechanical Analysis Methods to Assess Professional Badminton Players' Lunge Performance

Published on: June 11, 2019

11.4K
Ole Isacson: Development of New Therapies for Parkinson's Disease
23:53

Ole Isacson: Development of New Therapies for Parkinson's Disease

Published on: April 29, 2007

8.5K

Related Experiment Videos

Last Updated: Feb 12, 2026

Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches
08:25

Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches

Published on: November 21, 2018

14.3K
Biomechanical Analysis Methods to Assess Professional Badminton Players' Lunge Performance
06:36

Biomechanical Analysis Methods to Assess Professional Badminton Players' Lunge Performance

Published on: June 11, 2019

11.4K
Ole Isacson: Development of New Therapies for Parkinson's Disease
23:53

Ole Isacson: Development of New Therapies for Parkinson's Disease

Published on: April 29, 2007

8.5K

Area of Science:

  • Developmental Biology
  • Genetics
  • Molecular Biology

Background:

  • Homeobox (Hox) genes encode transcription factors vital for embryonic development and morphogenesis.
  • Hox genes establish regional identity along embryonic axes.
  • Mutations in Hox genes can lead to severe developmental defects and impact viability.

Purpose of the Study:

  • To review current knowledge on the function and regulation of the Hoxa5 gene.
  • To highlight Hoxa5's critical role in skeletal and organ development.
  • To discuss Hoxa5's involvement in cancer.

Main Methods:

  • Phenotypic analysis of Hoxa5 mutant mice.
  • Review of existing literature on Hoxa5 gene regulation.
  • Examination of Hoxa5's role in various organ systems.

Main Results:

  • Hoxa5 is crucial for lung organogenesis, with mutations causing respiratory distress and death at birth.
  • Hoxa5 plays a significant role in skeletal regional specification.
  • Hoxa5 also influences digestive tract, thyroid, mammary gland, and ovary development.
  • Deregulated Hoxa5 expression is associated with cancer predisposition and progression.

Conclusions:

  • Hoxa5 is a key regulator of organogenesis, especially lung development, and skeletal patterning.
  • The Hoxa5 gene's expression is tightly controlled by transcriptional, epigenetic, and non-coding RNA mechanisms.
  • Hoxa5's multifaceted roles underscore its importance in development and disease.