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Related Concept Videos

MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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Osmoregulation in Fishes02:32

Osmoregulation in Fishes

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When cells are placed in a hypotonic (low-salt) fluid, they can swell and burst. Meanwhile, cells in a hypertonic solution—with a higher salt concentration—can shrivel and die. How do fish cells avoid these gruesome fates in hypotonic freshwater or hypertonic seawater environments?
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FISH - Fluorescent In-situ Hybridization02:07

FISH - Fluorescent In-situ Hybridization

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Fluorescence in situ hybridization, or FISH, was developed in the early 1980s and has quickly become one of the most widely used techniques in cytogenetics. Labeled probes are used to bind complementary DNA or RNA sequences on a chromosome or in a region within a cell. Earlier, the probes could only be obtained by cloning or reverse transcription of a DNA template. Currently, the probe oligonucleotides can be synthesized synthetically. Additionally, with the advancement of optical techniques,...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

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Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

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Fishing Into the MicroRNA Transcriptome.

Marcos E Herkenhoff1, Arthur C Oliveira1, Pedro G Nachtigall1

  • 1Laboratory of Genomics and Molecular Evolution, Department of Genetics, Institute of Biosciences of Botucatu, Sao Paulo State University, Botucatu, Brazil.

Frontiers in Genetics
|April 5, 2018
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) regulate key traits in farmed fish, impacting growth and health. This review explores miRNA research in aquaculture, offering insights for Neotropical fish and future manipulation strategies.

Keywords:
aquaculturefarm animalsgene expressionmicroRNAsteleost fish

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Area of Science:

  • Aquatic livestock research
  • Gene expression regulation
  • Molecular biology in aquaculture

Background:

  • MicroRNAs (miRNAs) are small, non-coding RNA molecules regulating gene expression.
  • They influence economically important traits like growth, muscle development, and immunity in farmed animals.
  • Recent research has identified and characterized miRNA repertoires in various fish species.

Purpose of the Study:

  • To review current advances in miRNA research in aquaculture, focusing on Neotropical and other key fish species.
  • To provide insights into miRNA functions and their role in aquatic livestock.
  • To discuss future research directions and strategies for miRNA manipulation in aquaculture.

Main Methods:

  • Literature review of existing studies on fish miRNA repertoires and functions.
  • Horizontal comparison of major findings across different fish species.
  • Analysis of current and emerging strategies for miRNA manipulation.

Main Results:

  • The miRNA repertoire has been identified in several farmed fish species, revealing their regulatory roles.
  • MiRNAs are key regulators of economically valuable traits in aquatic livestock.
  • Existing data provides a foundation for understanding miRNA functions in Neotropical fish.

Conclusions:

  • Understanding fish miRNA repertoires offers novel perspectives for improving aquaculture health and productivity.
  • Future research on Neotropical fish can leverage existing knowledge for targeted miRNA studies.
  • Advanced miRNA manipulation strategies hold promise for enhancing fish farming outcomes.