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Non-comedogenic and non-acnegenic claim substantiation
Craig Weiss1, Michael Caswell1
1Consumer Product Testing Company, Inc., Fairfield, NJ 07004.
Journal of Cosmetic Science
|April 5, 2018
Summary
Two methods assess skin comedogenicity: an inexpensive human model and costly clinical trials. This study evaluates and contrasts their qualifications for supporting comedogenicity claims.
Area of Science:
- Dermatology
- Toxicology
- Cosmetic Science
Background:
- Comedogenicity, the potential of a substance to cause comedones (blackheads and whiteheads), is a critical factor in cosmetic and dermatological product safety.
- Accurate assessment of comedogenicity is essential for consumer safety and regulatory compliance.
Purpose of the Study:
- To evaluate and contrast the qualifications of two primary methods used for assessing skin comedogenicity.
- To determine the suitability of the human model versus human clinical trials for substantiating comedogenicity claims.
Main Methods:
- Comparison of the inexpensive human model (Mills and Kligman, modified) with the gold standard human clinical trial.
- Evaluation of the scientific validity and cost-effectiveness of each method.
Main Results:
- The human model offers a cost-effective preliminary assessment.
- Human clinical trials provide the definitive, gold standard evaluation for comedogenicity.
Conclusions:
- Both methods have distinct roles in evaluating comedogenicity.
- The choice of method depends on the required level of certainty and resource availability for substantiating claims.
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