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Related Experiment Video

Updated: Feb 12, 2026

In Ovo Intravascular Injection in Chicken Embryos

In Ovo Intravascular Injection in Chicken Embryos

Published on: June 3, 2022

A snail tale and the chicken embryo.

M Angela Nieto¹

¹Instituto de Neurociencias, CSIC-UMH, Sant Joan d´Alacant, Spain. anieto@umh.es.

The International Journal of Developmental Biology

|April 5, 2018

Summary

Chicken Snail2 was identified as the first transcription factor to induce epithelial-mesenchymal transition (EMT). This discovery, aided by chick embryo studies, is crucial for understanding cell migration in development and cancer.

Area of Science:

Developmental Biology
Molecular Biology
Cancer Research

Background:

The chicken embryo has been instrumental in understanding fundamental biological processes.
Cell migration is a critical process in embryonic development and disease progression.

Observation:

A chicken clone identified 25 years ago contained sequences for the Snail2 gene.
The chick embryo model provided insights into cell migration mechanisms.

Findings:

Snail2 was identified as the first transcription factor capable of inducing the epithelial-mesenchymal transition (EMT).
EMT is a key cellular process enabling cell migration.

Implications:

Understanding Snail2's role in EMT is vital for deciphering embryonic development.

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In Ovo Intravascular Injection in Chicken Embryos

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Targeting Snail2-induced EMT could offer new therapeutic strategies for cancer metastasis.