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The Role of Dendritic and Endothelial Cells in Cardiorenal Syndrome

Grazia Maria Virzì1,2, Jun Zhang3, Federico Nalesso1,2

  • 1Department of Nephrology, Dialysis and Transplant, San Bortolo Hospital, Vicenza, Italy.

Cardiorenal Medicine
|April 5, 2018
PubMed

Insights

Dendritic cells (DCs) and endothelial cells (ECs) are crucial in cardiorenal syndrome (CRS). Understanding their immune roles offers new therapeutic strategies for this complex condition.

Area of Science:

  • Immunology
  • Cardiology
  • Nephrology

Background:

  • Dendritic cells (DCs) are key antigen-presenting cells in immune responses.
  • Cardiorenal syndrome (CRS) involves complex interactions between cardiac and renal systems.
  • The specific roles of cardiac and renal DCs, and endothelial cells (ECs) in CRS pathogenesis are not fully understood.

Purpose of the Study:

  • To review the role of dendritic cells (DCs) in cardiorenal syndrome (CRS).
  • To explore the contribution of endothelial cells (ECs) to immune responses in CRS.
  • To propose a central role for DCs in all types of CRS and discuss EC involvement.

Main Methods:

  • Literature review focusing on DCs and ECs in cardiorenal syndrome (CRS).
  • Examination of existing data on DCs in animal models of CRS.
  • Synthesis of current knowledge on immune cell involvement in CRS.

Main Results:

  • DC and EC activation and dysfunction are central to CRS pathogenesis.
  • DCs are proposed to play a significant role across all types of CRS.
  • The potential of ECs to act as antigen-presenting cells or synergize with DCs in CRS is highlighted.

Conclusions:

  • Dendritic cells (DCs) are pivotal in the immune response within cardiorenal syndrome (CRS).
  • Endothelial cells (ECs) also contribute to immune responses in the context of CRS.
  • Further understanding of DC and EC roles may unlock novel therapeutic targets for CRS.
Abstract

Keywords:
Antigen-presenting cellsCardiorenal syndromeDendritic cellsEndothelial cellsEndothelial dysfunctionImmune dysregulation

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