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Targeting interleukin-22 for cancer therapy.
Anamarija Markota1, Stefan Endres1,2, Sebastian Kobold1,2
1a Center of Integrated Protein Science Munich (CIPS-M) and Division of Clinical Pharmacology, Department of Medicine IV , Klinikum der Universität München, Munich, Germany; Member of the German Center for Lung Research (DZL).
Human Vaccines & Immunotherapeutics
|April 5, 2018
Summary
Interleukin-22 (IL-22) promotes cancer, but understanding its regulation by cancer cells via IL-1 in T cells offers new therapeutic targets for cancer immunotherapy.
Area of Science:
- Immunology
- Oncology
Background:
- Interleukin-22 (IL-22) is an IL-10 family cytokine involved in tissue repair and host defense.
- Dysregulation of the IL-22-IL-22R1 system is linked to various cancers, including lung, breast, gastric, pancreatic, and colon cancers.
- IL-22 is produced by T cells and innate lymphoid cells, with its receptor IL-22R1 expressed on non-hematopoietic cells, making the pathway a target for anti-cancer therapy.
Purpose of the Study:
- To understand IL-22 regulation within the tumor microenvironment for developing novel anti-cancer therapies.
- To elucidate the mechanism by which cancer cells promote IL-22 production by memory T cells.
Main Methods:
- Investigated the role of IL-1 in mediating cancer cell-induced IL-22 production.
- Analyzed the IL-22-IL-22R1 pathway in the context of tumor microenvironment and cancer progression.
Main Results:
- Deciphered a mechanism where cancer cells induce IL-1 to promote IL-22 production by memory T cells.
- Highlighted the IL-22-IL-22R1 pathway as a critical component in cancer development.
Conclusions:
- Understanding cancer cell-driven IL-22 regulation via IL-1 provides insights for developing targeted cancer immunotherapies.
- Targeting the IL-22 pathway holds promise for future cancer treatment strategies.
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