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Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
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Early Clinical Results of Perceval Sutureless Aortic Valve in 139 Patients: Freeman Experience

Syed Saleem Mujtaba1, Simon Ledingham1, Asif Raza Shah1

  • 1Department of Cardiothoracic Surgery, Freeman Hospital, Freeman Road, United Kingdom of Great Britain and Northern Ireland.

Brazilian Journal of Cardiovascular Surgery
|April 5, 2018
PubMed
Abstract

Insights

The Perceval sutureless valve demonstrates safety in aortic valve replacement, with a 97.1% successful implant rate and low 30-day mortality. Further studies are needed for long-term outcomes.

Area of Science:

  • Cardiovascular Surgery
  • Bioprosthetic Devices
  • Surgical Outcomes

Background:

  • Aortic valve replacement is a critical procedure for patients with severe aortic valve disease.
  • Sutureless bioprosthetic valves offer potential advantages in reducing cross-clamp and bypass times.
  • The Perceval valve is a novel sutureless option for aortic valve replacement.

Purpose of the Study:

  • To evaluate the safety and performance of the Perceval sutureless valve in patients undergoing aortic valve replacement.
  • To report the 30-day clinical outcomes of patients who received the Perceval valve.
  • To assess early complications and hemodynamic performance of the Perceval valve.

Main Methods:

  • Retrospective study of 139 patients undergoing aortic valve replacement with the Perceval valve from January 2014 to December 2016.
  • Data collected from operation notes, National Adult Cardiac Surgery Database, and perioperative transesophageal echocardiography.
  • Patients categorized into isolated aortic valve replacement (n=92) and combined procedures (n=47).

Main Results:

  • Successful implantation of the Perceval valve in 97.1% of patients (135/139).
  • Low 30-day mortality (2.1%, 3/139), with major complications including stroke (4 patients) and acute renal failure (5 patients).
  • Mean gradient of 12.5 mmHg and effective orifice area of 1.5 cm² indicate good hemodynamic function. Four valves were explanted due to paravalvular leak.

Conclusions:

  • The Perceval sutureless valve is safe for early postoperative outcomes in aortic valve replacement.
  • The valve demonstrates acceptable hemodynamic performance in the early postoperative period.
  • Long-term follow-up is necessary to fully ascertain the durability and clinical efficacy of this bioprosthesis.

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