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Updated: Feb 12, 2026
The Intra-Aortic Balloon Pump
Published on: February 5, 2021
Hemolysis and Inflammatory Response to Extracorporeal Circulation during On-Pump CABG: Comparison between Roller and
Andréia Cristina Passaroni1, Marcello Laneza Felicio1, Nelson Leonardo Kerdahi Leite de Campos1
1Discipline of Cardiovascular Surgery, Department of Surgery and Orthopedics, Hospital das Clínicas da Faculdade de Medicina de Botucatu da Universidade Estadual Paulista (HCFMB-UNESP), Botucatu, SP, Brazil.
Insights
This study found no significant differences in hemolysis or inflammation between centrifugal and roller pumps during coronary artery bypass grafting. However, associations between these markers and bypass duration varied between pump types.
Area of Science:
- Cardiovascular Surgery
- Biomedical Engineering
- Intensive Care Medicine
Background:
- Cardiopulmonary bypass (CPB) is essential for coronary artery bypass grafting (CABG).
- Centrifugal and roller pumps are the primary technologies used for CPB.
- Understanding their impact on patient physiology, specifically hemolysis and inflammation, is crucial for optimizing surgical outcomes.
Purpose of the Study:
- To compare perioperative hemolysis and inflammatory responses in CABG patients using centrifugal versus roller pumps.
- To investigate correlations between hemolytic and inflammatory markers during CPB.
Main Methods:
- A prospective, randomized trial involving 60 CABG patients.
- Patients were assigned to either roller pump (n=30) or centrifugal pump (n=30) bypass.
- Serum haptoglobin, lactate dehydrogenase (LDH), interleukin-1ß (IL-1ß), IL-6, and tumor necrosis factor-alpha (TNF-α) were measured and analyzed.
Main Results:
- No significant differences in hemolysis or inflammation markers were observed between the centrifugal and roller pump groups.
- In the roller pump group, IL-6 and TNF-α correlated positively with CPB duration.
- In the centrifugal pump group, LDH correlated positively with CPB duration.
- Significant associations between hemolysis and inflammation markers were more frequent in the roller pump group.
Conclusions:
- Both centrifugal and roller pumps demonstrate comparable safety profiles regarding perioperative hemolysis and inflammation in CABG.
- The duration of cardiopulmonary bypass influences specific markers of hemolysis and inflammation differently depending on the pump type used.
- The roller pump group exhibited a higher rate of significant associations between hemolysis and inflammatory markers, suggesting potential differences in their interaction.
Objective:
To compare the perioperative incidence rates of hemolysis and inflammatory response in patients undergoing coronary artery bypass grafting with the two main types of cardiopulmonary bypass, centrifugal and roller pumps, and establish correlations among hemolytic and inflammatory changes.
Methods:
This was a prospective, randomized trial of 60 patients assigned to either roller pump (G1, n=30) or centrifugal pump (G2, n=30) bypass. Markers of hemolysis (serum haptoglobin, lactate dehydrogenase [LDH]) and inflammation (interleukin [IL]1ß, IL-6, and TNF-α) were measured and analyzed.
Results:
There was no significant between-group difference in the variables of interest. In G1, there was a positive association with IL-6 and TNF-α (P<0.01 and P<0.05, respectively). In G2, there was a positive association with LDH in the postoperative period (P<0.5). At 24h post-cardiopulmonary bypass, there were positive associations between LDH and IL-1ß (P<0.05), LDH and TNF-α (P<0.01), haptoglobin and TNF-α (P<0.05), and LDH and TNF-α (P<0.01) in G1, and between LDH and IL-6 (P<0.01), LDH and TNF-α (P<0.01), and LDH and IL-6 (P<0.01) in G2.
Conclusion:
There were no significant between-group differences in markers of hemolysis or inflammation. IL-6 and TNF-α were positively associated with duration of cardiopulmonary bypass in G1, while LDH was positively associated with duration of cardiopulmonary bypass in G2. The rate of significant associations between markers of hemolysis and inflammation was higher in the roller pump group (G1).
Registration Number:
ReBEC (RBR-92b9dg).
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