Related Experiment Video

Updated: Feb 12, 2026

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
09:29

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Published on: September 30, 2016

14.5K

New horizons in systemic anti-cancer therapy in older people

J L Parry1, P S Hall1, J Young2

  • 1Edinburgh Cancer Research Centre, University of Edinburgh, Edinburgh EH4 2XR, UK.

Age and Ageing
|April 5, 2018
PubMed

Insights

Cancer treatment for older adults faces challenges due to under-representation in clinical trials. This review focuses on optimizing systemic anti-cancer therapy for seniors, improving patient selection, and managing treatment toxicity.

Area of Science:

  • Geriatric Oncology
  • Clinical Pharmacology

Background:

  • Cancer incidence rises with age, making older adults a growing patient population.
  • Older adults are under-represented in clinical trials, limiting evidence-based treatment guidelines.
  • Unique physiological and comorbidity factors complicate cancer treatment decisions in the elderly.

Purpose of the Study:

  • To review strategies for optimizing cancer treatment in older patients.
  • To focus on systemic anti-cancer therapies for the geriatric population.
  • To address challenges in patient selection, treatment tolerance, and novel agent toxicity.

Main Methods:

  • Literature review of studies on cancer treatment in older adults.
  • Analysis of factors influencing systemic anti-cancer therapy in the elderly.
  • Examination of newer anti-cancer agents and their toxicity profiles in older patients.

Main Results:

  • Older adults require tailored approaches to systemic anti-cancer therapy.
  • Patient selection criteria need refinement to include geriatric-specific assessments.
  • Strategies to improve treatment tolerance and manage unique toxicities are crucial for efficacy.

Conclusions:

  • Optimizing cancer care for older adults necessitates individualized treatment plans.
  • Further research and inclusion of seniors in clinical trials are essential.
  • Addressing age-related complexities in systemic therapy improves outcomes for elderly cancer patients.

More Related Videos

Cerenkov Luminescence Imaging CLI for Cancer Therapy Monitoring08:45

Cerenkov Luminescence Imaging CLI for Cancer Therapy Monitoring

Published on: November 13, 2012

14.3K
Protocols for Assessing Radiofrequency Interactions with Gold Nanoparticles and Biological Systems for Non-invasive Hyperthermia Cancer Therapy10:51

Protocols for Assessing Radiofrequency Interactions with Gold Nanoparticles and Biological Systems for Non-invasive Hyperthermia Cancer Therapy

Published on: August 28, 2013

11.3K

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.0K
Schwarzschild Radius and Event Horizon01:21

Schwarzschild Radius and Event Horizon

No object with a finite mass can travel faster than the speed of light in a vacuum. This fact has an interesting consequence in the domain of extremely high gravitational fields.
The minimum speed required to launch a projectile from the surface of an object to which it is gravitationally bound so that it eventually escapes the object’s gravitational field is called the escape velocity. The escape velocity is independent of the mass of the object. Merging the idea of escape...
2.8K
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K
Second Order systems II01:18

Second Order systems II

In an underdamped second-order system, where the damping ratio ζ is between 0 and 1, a unit-step input results in a transfer function that, when transformed using the inverse Laplace method, reveals the output response. The output exhibits a damped sinusoidal oscillation, and the difference between the input and output is termed the error signal. This error signal also demonstrates damped oscillatory behavior. Eventually, as the system reaches a steady state, the error diminishes to zero.
414
First Order Systems01:21

First Order Systems

First-order systems, such as RC circuits, are foundational in understanding dynamic systems due to their straightforward input-output relationship. Analyzing their responses to different input functions under zero initial conditions reveals significant insights into system behavior.
When a first-order system is subjected to a unit-step input, its response is characterized by its transfer function. By applying the Laplace transform of the unit-step input to the transfer function, expanding the...
435