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Updated: Feb 12, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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m6ASNP: a tool for annotating genetic variants by m6A function.

Shuai Jiang1,2, Yubin Xie2, Zhihao He2

  • 1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University, Guangzhou 510060, China.

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|April 5, 2018
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Summary
This summary is machine-generated.

m6ASNP identifies genetic variants impacting N6-methyladenosine (m6A) RNA modification sites. This tool aids researchers in understanding how genetic variations influence m6A methylation and disease.

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Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • Large-scale genome sequencing identifies numerous disease-associated genetic variants.
  • N6-methyladenosine (m6A) is a prevalent RNA modification in eukaryotes.
  • Aberrant m6A modifications are implicated in the pathogenesis of various diseases.

Purpose of the Study:

  • To develop a web server, m6ASNP, for identifying genetic variants that target m6A modification sites.
  • To facilitate the functional characterization of genetic variants in relation to m6A modification.

Main Methods:

  • Implemented a random forest model to predict the impact of variants on m6A methylation status.
  • Developed a user-friendly web server accepting genetic variants in VCF format.
  • Integrated an interactive table, statistical diagrams, and a genome browser for data visualization and annotation.

Main Results:

  • The m6ASNP web server successfully identifies genetic variants affecting m6A sites.
  • Provides annotated genetic variants with predicted m6A functional impact.
  • Offers visualization tools for exploring variant characteristics and genomic context.

Conclusions:

  • m6ASNP serves as a convenient tool for functional studies of genetic variants.
  • The web server aids in understanding the role of genetic variants in m6A modification.
  • m6ASNP is freely available and implemented in JAVA and PHP.