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Reactome Pengine: a web-logic API to the Homo sapiens reactome.

Samuel R Neaves¹, Sophia Tsoka¹, Louise A C Millard^2,3,4

¹Department of Informatics, King's College London, Strand, London, UK.

Bioinformatics (Oxford, England)

|April 5, 2018

Summary

This summary is machine-generated.

Reactome Pengine offers a flexible logic programming-based API for accessing human Reactome pathway data. This overcomes limitations of existing methods, allowing researchers custom data queries beyond predefined options.

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Area of Science:

Bioinformatics
Computational Biology
Systems Biology

Background:

Current Reactome database access methods are restrictive.
Researchers face limitations with predefined web application programming interfaces (APIs).
Downloading the entire Reactome database is often impractical.

Purpose of the Study:

Introduce Reactome Pengine, a novel web service.
Provide a logic programming-based API for the human Reactome.
Enhance flexibility in accessing Reactome pathway data.

Main Methods:

Developed a web service named Reactome Pengine.
Implemented a logic programming-based API.
Enabled users to submit custom programs with queries.

Main Results:

Reactome Pengine offers greater data access flexibility compared to existing APIs.
Users can now perform custom analyses on human Reactome data.
The service provides a more adaptable approach to biological pathway data retrieval.

Conclusions:

Reactome Pengine significantly improves data accessibility for Reactome users.
The logic programming approach empowers researchers with tailored data exploration.
This tool facilitates more sophisticated analysis of biological pathways.