Related Experiment Video

Updated: Feb 12, 2026

Purification and Visualization of Influenza A Viral Ribonucleoprotein Complexes
09:35

Purification and Visualization of Influenza A Viral Ribonucleoprotein Complexes

Published on: February 9, 2009

13.4K

Non-mumps Viral Parotitis During the 2014-2015 Influenza Season in the United States

Lina I Elbadawi1,2, Pamela Talley1,3, Melissa A Rolfes1,4

  • 1Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|April 5, 2018
PubMed
Abstract

Insights

During the 2014-2015 influenza season, non-mumps parotitis (NMP) was investigated. Influenza A(H3N2), human herpesvirus 6B, and Epstein-Barr virus were common causes, suggesting broader differential diagnoses for parotitis.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Investigated an unusual increase in non-mumps parotitis (NMP) cases during the 2014-2015 US influenza season.
  • Collected data on 320 NMP cases across 21 states reported to the CDC.

Purpose of the Study:

  • Determine the viral causes of NMP.
  • Characterize the clinical features of NMP cases.

Main Methods:

  • Defined NMP as salivary gland swelling with negative mumps testing.
  • Collected demographic and clinical data via questionnaire.
  • Tested buccal samples for a panel of viruses including influenza, EBV, and HHVs.

Main Results:

  • Identified viral etiologies in 71% of NMP patients.
  • Influenza A(H3N2) was the most frequent virus (156 cases), followed by human herpesvirus 6B (42 cases) and Epstein-Barr virus (32 cases).
  • Coinfections with multiple viruses were observed.

Conclusions:

  • Clinicians should consider influenza and herpesviruses as causes of parotitis.
  • Differential diagnosis for parotitis should extend beyond mumps, especially in patients without mumps exposure.

More Related Videos

An Optimized Hemagglutination Inhibition HI Assay to Quantify Influenza-specific Antibody Titers06:34

An Optimized Hemagglutination Inhibition HI Assay to Quantify Influenza-specific Antibody Titers

Published on: December 1, 2017

38.1K
Fluorescence-based Neuraminidase Inhibition Assay to Assess the Susceptibility of Influenza Viruses to The Neuraminidase Inhibitor Class of Antivirals09:31

Fluorescence-based Neuraminidase Inhibition Assay to Assess the Susceptibility of Influenza Viruses to The Neuraminidase Inhibitor Class of Antivirals

Published on: April 15, 2017

19.1K

Related Concept Videos

Seasoning of Wood01:15

Seasoning of Wood

Seasoning of wood is a crucial process aimed at reducing and stabilizing the moisture content within the wood to prevent future shrinkage, structural damage, or aesthetic issues once the wood is used in construction. Wood naturally swells when it absorbs moisture and contracts as it dries.
Achieving equilibrium moisture content is the goal of seasoning; this is the point where the wood's moisture content stabilizes to align with the moisture levels of the surrounding environment. Proper...
525
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
41.8K
Measurement: Standard Units03:38

Measurement: Standard Units

Every measurement provides three kinds of information: the size or magnitude of the measurement (a number), a standard of comparison for the measurement (a unit), and an indication of the uncertainty of the measurement. While the number and unit are explicitly represented when a quantity is written, the uncertainty is an aspect of the errors in the measurement results.
82.2K
Measurement: Derived Units03:02

Measurement: Derived Units

The International System of Units or SI system, by international agreement, has fixed measurement units for seven fundamental properties: length, mass, time, temperature, electric current, amount of substance, and luminosity. These are called the SI base units.
56.0K
Viral Recombination00:57

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
25.2K
Viral Structure00:56

Viral Structure

Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
74.8K