Related Experiment Video

Updated: Feb 12, 2026

Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase COX/SDH Double-labeling Histochemistry
06:53

Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase COX/SDH Double-labeling Histochemistry

Published on: November 23, 2011

37.8K

Diagnostic Investigation of Lesions Associated with Succinate Dehydrogenase Defects

David Taïeb1, Henri Timmers2, Karel Pacak3

  • 1Department of Nuclear Medicine, La Timone University Hospital, CERIMED, Aix-Marseille University, Marseille, France.

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|April 5, 2018
PubMed

Insights

Succinate dehydrogenase (SDH) deficiency causes tumors like pheochromocytomas. This review explores imaging techniques and genotype-imaging links in SDH-deficient tumors.

Area of Science:

  • Biochemistry
  • Oncology
  • Genetics

Background:

  • Mitochondrial enzyme succinate dehydrogenase (SDH) functions as a tumor suppressor.
  • Inactivating mutations in SDH subunit genes (SDHx) cause loss of function and tumor development.
  • Pheochromocytomas and paragangliomas are hereditary tumors linked to SDH deficiency.

Purpose of the Study:

  • To review the role of imaging examinations in SDH-deficient tumors.
  • To present new insights into genotype-imaging phenotype relationships in these tumors.

Main Methods:

  • Literature review of imaging modalities for SDH-deficient tumors.
  • Analysis of genotype-imaging phenotype correlations.

Main Results:

  • Imaging plays a crucial role in diagnosing and characterizing SDH-deficient tumors.
  • Specific imaging features correlate with distinct SDHx mutations.
  • Understanding these relationships aids in personalized diagnosis and management.

Conclusions:

  • Imaging is essential for evaluating patients with suspected SDH-related tumors.
  • Genotype-imaging phenotype correlations offer valuable diagnostic and prognostic information.
  • Further research can refine imaging protocols for SDH deficiency.

More Related Videos

Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair10:59

Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair

Published on: May 24, 2017

10.1K
Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue06:18

Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue

Published on: June 21, 2018

12.1K

Related Concept Videos

Lumber Defects01:23

Lumber Defects

Lumber defects, which can affect both the appearance and structural integrity of wood, include a variety of growth and manufacturing flaws. Growth defects such as knots and knotholes occur where branches were once attached to the tree trunk, with knotholes forming when these knots fall out. Other natural defects include decay and insect damage, which compromise the wood's strength and durability.
Shakes are minor fractures that run along or across the wood's annual rings, while wane is...
562
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
600
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
2.7K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.2K
Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
347
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
568