An Inflammation-Centric View of Neurological Disease: Beyond the Neuron
Stephen D Skaper1, Laura Facci1, Morena Zusso1
1Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy.
Frontiers in Cellular Neuroscience
|April 6, 2018
Summary
Chronic inflammation in the nervous system (neuroinflammation) damages tissue and contributes to diseases. This review highlights mast cell-glia and glia-glia interactions in neuroinflammation and potential therapeutic strategies.
Area of Science:
- Neuroscience
- Immunology
- Pathology
Background:
- Inflammation is a biological response to injury or infection.
- Chronic inflammation, unlike acute, can cause tissue damage and disease.
- Neuroinflammation, prolonged inflammation in the nervous system, is particularly injurious.
Purpose of the Study:
- To review the current understanding of neuroinflammation.
- To emphasize the roles of mast cell-glia and glia-glia interactions.
- To explore therapeutic strategies targeting neuroinflammation.
Main Methods:
- Literature review of neuroinflammation.
- Focus on cell-cell interactions in the nervous system.
- Analysis of immune mediators and cell sources.
Main Results:
- Neuroinflammation contributes to various neurological diseases.
- Microglia, mast cells, astrocytes, and oligodendrocytes are key cell types.
- Mast cells play a crucial role in orchestrating neuroinflammation.
Conclusions:
- Understanding neuroinflammation requires appreciating cell-cell interactions.
- Targeting endogenous cellular mechanisms offers therapeutic potential.
- Further research into glia and mast cell interactions is warranted.
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