Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Evidence for Evolution02:55

The Evidence for Evolution

48.4K
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
48.4K
Muscles of the Leg that Move the Foot and Toes01:28

Muscles of the Leg that Move the Foot and Toes

4.2K
The human leg comprises an intricate system of muscles that facilitate the movement of feet and toes. Within this system, the muscles are categorized into the anterior, lateral, and posterior compartments, each with a unique set of muscles carrying out specific functions.
Anterior Compartment
The anterior compartment includes muscles that contribute to the dorsiflexion of the foot. This compartment houses the tibialis anterior, extensor hallucis longus, and extensor digitorum longus muscles....
4.2K
Sustainable Development01:43

Sustainable Development

15.2K
As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
15.2K
Language Development01:22

Language Development

936
Children master language quickly and with relative ease, supported by both biological predisposition and reinforcement. B. F. Skinner (1957) proposed that language is learned through reinforcement, while Noam Chomsky (1965) argued that language acquisition mechanisms are biologically determined.
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
936
Development of the Lymphatic System01:15

Development of the Lymphatic System

2.2K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
2.2K
Development of Immunocompetence01:22

Development of Immunocompetence

987
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
987

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions for disease elements in calcium pyrophosphate crystal deposition (CPPD).

Annals of the rheumatic diseases·2026
Same author

Reply to Shih-Wei Lai: Gout flares, serum urate, and lifestyle modification.

Clinical rheumatology·2026
Same author

Ask an expert: Gout.

BMJ (Clinical research ed.)·2026
Same author

Gout flares, serum urate and seasonality: a descriptive cohort study.

Clinical rheumatology·2026
Same author

Temporal Trends and Short- and Long-Term Mortality of People With Acute Myocardial Infarction and Rheumatoid Arthritis: A Nationwide Cohort Study.

Arthritis care & research·2025
Same author

Incidence and risk of nephrolithiasis with uricosuric therapies for the treatment of gout: a systematic review and meta-analysis of randomized controlled trials and cohort studies.

Rheumatology (Oxford, England)·2025

Related Experiment Video

Updated: Feb 12, 2026

Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain
07:19

Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Published on: March 24, 2023

6.1K

Foot osteoarthritis: latest evidence and developments.

Edward Roddy1, Hylton B Menz2

  • 1Reader in Rheumatology, Research Institute for Primary Care and Health Sciences, Keele University, Keele, Staffordshire, ST5 5BG, UK; and Haywood Academic Rheumatology Centre, Staffordshire and Stoke-on-Trent Partnership Trust, UK.

Therapeutic Advances in Musculoskeletal Disease
|April 6, 2018
PubMed
Summary

Foot osteoarthritis (OA) is common in older adults but under-researched. More studies are needed to understand its incidence, progression, and effective treatments for various foot joints.

Keywords:
epidemiologyfoot osteoarthritisrandomized controlled trialstreatment

More Related Videos

Evaluating the Function of the Foot Core System in the Elderly
08:25

Evaluating the Function of the Foot Core System in the Elderly

Published on: March 11, 2022

3.3K
Treatment of Ankle Osteoarthritis with Total Ankle Replacement Through a Lateral Transfibular Approach
09:01

Treatment of Ankle Osteoarthritis with Total Ankle Replacement Through a Lateral Transfibular Approach

Published on: January 24, 2018

12.4K

Related Experiment Videos

Last Updated: Feb 12, 2026

Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain
07:19

Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Published on: March 24, 2023

6.1K
Evaluating the Function of the Foot Core System in the Elderly
08:25

Evaluating the Function of the Foot Core System in the Elderly

Published on: March 11, 2022

3.3K
Treatment of Ankle Osteoarthritis with Total Ankle Replacement Through a Lateral Transfibular Approach
09:01

Treatment of Ankle Osteoarthritis with Total Ankle Replacement Through a Lateral Transfibular Approach

Published on: January 24, 2018

12.4K

Area of Science:

  • Rheumatology
  • Orthopedics
  • Epidemiology

Background:

  • Foot osteoarthritis (OA) is prevalent in older adults, yet research lags behind knee or hand OA.
  • Existing studies predominantly focus on the first metatarsophalangeal joint, with limited data on midfoot OA.
  • Symptomatic radiographic foot OA impacts 17% of adults aged 50+, primarily affecting the first metatarsophalangeal, second cuneometatarsal, and talonavicular joints.

Purpose of the Study:

  • To highlight the under-researched nature of foot OA compared to other joints.
  • To identify key affected joints and potential distinct OA phenotypes.
  • To underscore the need for more robust epidemiological data and clinical trials.

Main Methods:

  • Review of existing epidemiological studies on foot OA prevalence and joint involvement.
  • Analysis of current evidence from randomized controlled trials (RCTs) on interventions for foot OA.
  • Identification of research gaps in incidence, progression, prognosis, and novel treatments.

Main Results:

  • The first metatarsophalangeal joint is the most frequently affected site in foot OA.
  • Distinct first metatarsophalangeal joint and polyarticular OA phenotypes may exist with different risk profiles.
  • Limited RCTs exist, with some evidence for physical therapy, specialized footwear, orthoses, and surgery in first metatarsophalangeal OA, and prefabricated orthoses in midfoot OA.

Conclusions:

  • Foot OA, particularly midfoot OA, requires further dedicated research.
  • Prospective studies are essential to determine foot OA incidence, progression, and prognosis.
  • More randomized trials are needed to evaluate existing and novel interventions for effective pain relief and management.