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Metabolomics of oncogene-specific metabolic reprogramming during breast cancer

Chen Dai1,2, Jennifer Arceo1,2, James Arnold3

  • 11Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556 USA.

Cancer & Metabolism
|April 6, 2018
PubMed
Abstract

Insights

This study reveals how specific oncogenes reprogram breast tumor metabolism in mice, identifying a metabolic signature linked to patient prognosis. These findings highlight potential new biomarkers and therapeutic targets in breast cancer.

Area of Science:

  • Oncology
  • Metabolomics
  • Genomics

Background:

  • The interplay between cancer metabolism and oncogenic driver genes is crucial but underexplored.
  • Understanding these connections can yield novel biomarkers and therapeutic targets for breast cancer.

Purpose of the Study:

  • To investigate global metabolic profiles in breast tumors from transgenic mouse models.
  • To identify unique metabolic signatures driven by specific oncogenes.

Main Methods:

  • Utilized mass spectrometry (GC-MS, LC-MS/MS) and capillary zone electrophoresis-MS (CZE-MS) to quantify 374 metabolites.
  • Compared metabolic profiles from normal and transgenic mouse breast cancer models overexpressing various oncogenes.
  • Integrated mouse metabolomics data with published human metabolomics data.

Main Results:

  • Identified distinct metabolic differences between normal and tumor breast tissues, as well as oncogene-specific metabolic signatures.
  • The C3-TAg oncogene model exhibited a metabolic signature of ten metabolites with significant prognostic value in human breast cancer patients.
  • Gene expression analysis suggested candidate genes involved in metabolic reprogramming.

Conclusions:

  • Demonstrated oncogene-induced metabolic reprogramming in mouse breast tumors.
  • Provided a comparative analysis with human breast tumors, linking oncogene-driven metabolism to clinical value in breast cancer.
Keywords:
Breast cancerMetabolic reprogrammingMetabolomicsOncogeneTransgenic mouse model

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