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Inherited seborrheic dermatitis--a new mutant in mice
H Höger1, J Gialamas, D Adamiker
1Versuchstierzucht und -haltung der Medizinischen, Fakultät der Universität Wien, Austria.
Laboratory Animals
|October 1, 1987
Summary
A new mutation in Him:OF1 mice causes inherited seborrheic dermatitis, affecting skin and hair. This autosomal recessive trait results in sparse fur, reduced viability, and fertility in affected mice.
Area of Science:
- Genetics
- Dermatology
- Animal Models
Background:
- A spontaneous mutation arose in an Him:OF1 mouse colony.
- The mutation affects skin and hair characteristics.
Purpose of the Study:
- To identify the genetic basis of the observed skin and hair mutation.
- To characterize the phenotype associated with the mutation.
Main Methods:
- Test crosses were performed to determine the mode of inheritance.
- Histological examination of affected tissues was conducted.
Main Results:
- The trait is controlled by a single autosomal recessive gene.
- Homozygotes exhibit sparse, greasy fur, reduced viability, and impaired fertility.
- Histology revealed sebaceous gland hypertrophy, hyperkeratosis, parakeratosis, acanthosis, and inflammation.
Conclusions:
- A novel mutation causing inherited seborrheic dermatitis has been identified in Him:OF1 mice.
- The gene responsible has been proposed to be named 'seb'.