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Association of Gene Mutations with Response to Arsenic-Containing Compound Qinghuang Powder () in Patients with

Pan Zhao¹, Jun-Bin Liang², Zhong-Yang Deng¹

¹Department of Hematology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.

Chinese Journal of Integrative Medicine

|April 6, 2018

Abstract

Objectives:

To investigate the relationship between gene mutations and response to Compound Qinghuang Powder (, CQHP) in patients with myelodysplastic syndrome (MDS).

Methods:

Forty-three MDS patients were genotyped by ultra-deep targeted sequencing and the clinical data of patients were collected and the relationship between them was analyzed.

Results:

Up to 41.86% of patients harbored genet mutations, in most cases with more than one mutation. The most common mutations were in SF3B1, U2AF1, ASXL1, and DNMT3A. After treatment with CQHP, about 88.00% of patients no longer required blood transfusion, or needed half of prior transfusions.

Conclusions:

CQHP is an effective treatment for patients with MDS, especially those with gene mutations in SF3B1, DNMT3A, U2AF1, and/or ASXL1.

Keywords:

arsenic myelodysplastic syndromes next-generation sequencing realgar

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