Macromolecular diffusion in crowded media beyond the hard-sphere model

Related Experiment Video

Updated: Feb 12, 2026

In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding
08:20

In Vitro Model of Human Cutaneous Hypertrophic Scarring using Macromolecular Crowding

Published on: May 1, 2020

7.2K

Pablo M Blanco1, Josep Lluís Garcés2, Sergio Madurga1

  • 1Department of Material Science and Physical Chemistry, Barcelona University, 08028 Barcelona, Spain. fmas@ub.edu pmblanco@ub.edu s.madurga@ub.edu and Institute of Theoretical and Computational Chemistry (IQTC), Barcelona University, 08028 Barcelona, Spain.

Soft Matter
|April 6, 2018
PubMed

More Related Videos

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding09:14

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding

Published on: August 22, 2016

13.0K
Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes10:43

Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes

Published on: July 19, 2022

2.9K

Related Concept Videos

Diffusion01:12

Diffusion

Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
221.8K
Diffusion01:21

Diffusion

Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
6.5K
Toughness and Hardness of Aggregate01:22

Toughness and Hardness of Aggregate

Toughness and hardness are critical properties of aggregate materials used in concrete, particularly on pavement surfaces and industrial flooring subjected to heavy loads. Toughness is defined as the aggregate's resistance to failure by impact and is measured by the aggregate impact value (AIV). For this, the aggregate impact value test is performed, wherein the impact is delivered by a standard hammer, which falls freely under its own weight onto the aggregates. The aggregates fragment in...
641
Theories of Dissolution: Diffusion Layer Model01:15

Theories of Dissolution: Diffusion Layer Model

Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
1.8K
Electric Field of a Non Uniformly Charged Sphere01:22

Electric Field of a Non Uniformly Charged Sphere

Gauss's law states that the electric flux through any closed surface equals the net charge enclosed within the surface. This law is beneficial for determining the expressions for the electric field for a particular charge distribution if the electric flux is known.
Consider a non-uniformly charged sphere, for which the density of charge depends only on the distance from a point in space and not on the direction. Such a sphere has a spherically symmetrical charge distribution. Here, the electric...
2.3K
Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models00:57

Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models

Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...
353