Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Abuse and Addiction: Pharmacological Phenomena

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Virtual charter students have worse labor market outcomes as young adults.

Social science research·2026

Same author

Psychotropic-Induced Reversible Cerebral Vasoconstriction Syndrome in a Young Man Taking Sertraline.

The primary care companion for CNS disorders·2026

Same author

Peer income exposure across the income distribution.

Proceedings of the National Academy of Sciences of the United States of America·2025

Same author

Psychotropic Management in Cotard Syndrome: Case Reports Supporting Dual Medication Management.

Case reports in psychiatry·2024

Same author

A Case of Neuroleptic Malignant Syndrome in the Context of Lithium Toxicity and Aripiprazole Use.

Clinical neuropharmacology·2023

Same author

Anti-PD-1 therapy in advanced sarcomas: is cutaneous primary site a stronger predictor of response than histologic subtype?

Cancer immunology, immunotherapy : CII·2023

Same journal

Are the 8 Finnish Deaths Explained by Agranulocytosis More Important than the Thousands of Suicide Deaths Associated with the Lack of Use of Clozapine? Reflections on Clozaphobia.

Journal of clinical psychopharmacology·2026

Same journal

Aripiprazole Withdrawal-Associated Restless Legs Syndrome During Clozapine Treatment in an Adolescent With Schizoaffective Disorder: A Case Report.

Journal of clinical psychopharmacology·2026

Same journal

Salute to Our Reviewers.

Journal of clinical psychopharmacology·2026

Same journal

Article Selected to Receive the Mitchell B. Balter Award for Publications in 2025.

Journal of clinical psychopharmacology·2026

Same journal

Pregnancy Outcomes After First-Trimester Exposure to Vortioxetine: Prospective Outcomes From the MGH National Pregnancy Registry for Psychiatric Medications.

Journal of clinical psychopharmacology·2026

Same journal

Salute to Our Reviewers.

Journal of clinical psychopharmacology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 12, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

Doxepin: Misuse and Abuse

Benjamin Spurling¹, Leah Clark, Adam J Fusick

¹Department of Psychiatry University of South Florida Morsani College of Medicine Tampa, FL. Psychiatry Consult Service James A. Haley VA Hospital and University of South Florida College of Medicine Tampa, FL william.whiting@va.gov.

Journal of Clinical Psychopharmacology

|April 6, 2018

Summary

No abstract available in PubMed .

More Related Videos

Intranuclear Microinjection of DNA into Dissociated Adult Mammalian Neurons

Intranuclear Microinjection of DNA into Dissociated Adult Mammalian Neurons

Published on: December 10, 2009

Chronic Social Defeat Stress in Early Adolescent Male Mice

Chronic Social Defeat Stress in Early Adolescent Male Mice

Published on: January 24, 2025

Related Experiment Videos

Last Updated: Feb 12, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

Intranuclear Microinjection of DNA into Dissociated Adult Mammalian Neurons

Intranuclear Microinjection of DNA into Dissociated Adult Mammalian Neurons

Published on: December 10, 2009

Chronic Social Defeat Stress in Early Adolescent Male Mice

Chronic Social Defeat Stress in Early Adolescent Male Mice

Published on: January 24, 2025