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Anticholinergic therapy in chronic asthma.

G M Sterling1

  • 1General Hospital, Southampton, UK.

Postgraduate Medical Journal
|January 1, 1987
PubMed
Summary

Anticholinergic agents like ipratropium bromide offer prolonged bronchodilation for chronic asthma, comparable to beta-agonists without impairing sputum clearance. These agents are a safe addition to existing asthma treatments.

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Area of Science:

  • Pulmonology
  • Pharmacology

Background:

  • Chronic asthma, often defined as non-allergic or intrinsic asthma in adults, presents unique treatment challenges.
  • Current treatments may have limitations or side effects impacting patient management.

Purpose of the Study:

  • To evaluate the efficacy and safety of anticholinergic agents as a bronchodilator in adult patients with chronic asthma.
  • To compare the bronchodilator effects of anticholinergic agents with beta-agonists.

Main Methods:

  • The study focused on patients diagnosed with chronic, non-allergic asthma.
  • Efficacy was assessed by the bronchodilator action and duration of effect of anticholinergic agents.
  • Safety was evaluated, with specific attention to effects on sputum clearance.

Main Results:

  • Anticholinergic agents, specifically ipratropium bromide, demonstrated a significant and prolonged bronchodilator effect.
  • The bronchodilation achieved was comparable to that of therapeutic doses of beta-agonists.
  • No adverse effects on sputum clearance were observed with anticholinergic agent use.

Conclusions:

  • Anticholinergic agents are a safe and effective bronchodilator for managing chronic asthma.
  • These agents serve as a valuable adjunct to other bronchodilator therapies in this patient population.
  • Ipratropium bromide offers a beneficial treatment option for intrinsic adult-onset asthma.

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