CLINICAL CHARACTERISTICS AND ANTIBIOTIC RESISTANCE PATTERN OF PATHOGENS IN PEDIATRIC URINARY TRACT INFECTION

Area of Science:

• Pediatric Infectious Diseases
• Microbiology
• Antimicrobial Resistance

Background:

• Urinary tract infections (UTIs) are common in children.
• Escherichia coli is a frequent cause of pediatric UTIs.
• Antimicrobial resistance is a growing concern in treating bacterial infections.

Purpose of the Study:

• To investigate the prevalence of pathogens causing upper UTIs in children.
• To determine the antimicrobial resistance patterns of Escherichia coli in pediatric UTIs.
• To assess the prevalence of extended spectrum beta-lactamase (ESBL) producing E. coli in pediatric UTIs.

Main Methods:

• Retrospective review of medical records of children under 15 admitted for UTI from January 2010 to December 2014.
• Identification of bacterial pathogens and antimicrobial susceptibility testing.
• Categorization of E. coli isolates as non-ESBL or ESBL producers.

Main Results:

• 100 children with upper UTI were analyzed; 59% males and 41% females.
• Escherichia coli was the most common pathogen (88%), with 69% non-ESBL and 19% ESBL producers.
• High resistance rates were observed: 90% to ampicillin and 60% to trimethoprim/sulfamethoxazole. All ESBL producers were resistant to ampicillin and third-generation cephalosporins.

Conclusions:

• There is a high prevalence of ESBL-producing E. coli in pediatric UTIs.
• Antimicrobial resistance, particularly to common antibiotics, poses a significant challenge in treating these infections.
• The findings underscore the need for vigilant monitoring and appropriate treatment strategies for pediatric UTIs.