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Updated: Feb 12, 2026

Double-barreled and Concentric Microelectrodes for Measurement of Extracellular Ion Signals in Brain Tissue
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Double-barreled gun: Combination of PARP inhibitor with conventional chemotherapy

Yanxin Lu1, Yang Liu2, Ying Pang3

  • 1Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA; Basic Medical Science Department, Zunyi Medical College-Zhuhai Campus, Zhuhai, Guangdong 519041, PR China.

Pharmacology & Therapeutics
|April 6, 2018
PubMed

Insights

Poly (ADP-ribose) polymerase (PARP) inhibitors are crucial in cancer therapy, improving outcomes by targeting DNA repair mechanisms. This review summarizes their use, especially in combination therapies, for enhanced tumor suppression.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • DNA repair pathways are essential for maintaining genomic integrity.
  • The activity of DNA repair pathways influences cancer therapy resistance and patient outcomes.
  • Poly (ADP-ribose) polymerase (PARP) enzymes play a key role in DNA repair and can counteract chemotherapy.

Purpose of the Study:

  • To review the pre-clinical and clinical findings on the application of PARP inhibitors in cancer therapy.
  • To highlight the potential of PARP inhibitors, particularly in combination therapies.

Main Methods:

  • Literature review of pre-clinical studies on PARP inhibitors.
  • Analysis of clinical trial data for PARP inhibitor efficacy.
  • Examination of combination therapy strategies involving PARP inhibitors.

Main Results:

  • PARP inhibitors have significantly advanced cancer treatment concepts over the past three decades.
  • These inhibitors show encouraging improvements in tumor suppression and disease outcomes.
  • Their application, especially in combination therapies, is a key area of research.

Conclusions:

  • PARP inhibitors represent a significant therapeutic advancement in oncology.
  • Combination therapies involving PARP inhibitors hold great promise for improving cancer treatment efficacy.
  • Further research into PARP inhibitor applications is warranted to optimize patient outcomes.
Keywords:
CancerChemoresistanceChemotherapyCombination therapyDNA repairPARP inhibitor

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