Intensity-modulated radiation therapy: a review with a physics perspective

Area of Science:

• Radiation oncology
• Medical physics
• Radiotherapy technology

Background:

• Intensity-modulated radiation therapy (IMRT) is a significant advancement in radiation oncology, building upon 3D conformal radiotherapy.
• The concept of inverse planning for IMRT was introduced in 1982, revolutionizing treatment strategies.
• IMRT has become a cornerstone modality in modern radiation therapy over the past three decades.

Purpose of the Study:

• To review the advancements in inverse treatment planning for IMRT.
• To discuss the developments in IMRT delivery using multileaf collimators.
• To present key concepts, current issues, and future perspectives in IMRT.

Main Methods:

• Literature review of developments in inverse IMRT planning.
• Analysis of IMRT delivery techniques utilizing multileaf collimators.
• Synthesis of key concepts and future trends in the field.

Main Results:

• IMRT has evolved significantly since its inception, becoming a standard in radiation oncology.
• Inverse planning and multileaf collimator technology have been crucial to IMRT's success.
• The review consolidates historical progress and outlines future research avenues.

Conclusions:

• IMRT, particularly with inverse planning, is a highly successful and widely adopted radiotherapy technique.
• Continued innovation in treatment planning and delivery is essential for advancing IMRT.
• The field is poised for further developments addressing current challenges and exploring new possibilities.