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Dolutegravir as a trigger for DRESS syndrome?
Charlotte Martin1, Marie-Christine Payen1, Stephane De Wit1
1Department of Infectious Diseases, Saint-Pierre University Hospital, Université Libre de Bruxelles (ULB), Brussels, Belgium.
International Journal of STD & AIDS
|April 7, 2018
Summary
Dolutegravir, an HIV integrase inhibitor, has not been previously linked to Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome. This study reports the first known case of DRESS syndrome associated with dolutegravir use.
Area of Science:
- Pharmacovigilance
- Infectious Diseases
- Dermatology
Background:
- Dolutegravir is a widely prescribed second-generation integrase strand transfer inhibitor for human immunodeficiency virus (HIV) treatment.
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a severe, idiosyncratic drug reaction.
- Previous reports have documented DRESS syndrome associated with raltegravir, another integrase inhibitor.
Observation:
- This report details a case of DRESS syndrome in a patient receiving dolutegravir.
- The patient presented with characteristic symptoms and laboratory findings of DRESS syndrome.
Findings:
- This is the first documented case of DRESS syndrome linked to dolutegravir.
- The findings suggest that dolutegravir, despite its class, may also be associated with DRESS syndrome.
Implications:
- Clinicians should be aware of the potential for DRESS syndrome with dolutegravir.
- Further pharmacovigilance is warranted to monitor for DRESS syndrome in patients treated with dolutegravir.
- This case expands the understanding of potential adverse drug reactions associated with integrase strand transfer inhibitors.
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