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Related Experiment Videos

A potent hypotensive factor in chicken left ventricle.

T Reilly1, C M Gregg, R F Wideman

  • 1Department of Biology, Pennsylvania State University, University Park 16802.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
|December 1, 1987
PubMed
Summary

Chicken heart granules, potentially similar to mammalian atriopeptin (ANP), were investigated. The left ventricle extract showed potent hypotensive activity in chickens, but weaker effects in rats, suggesting it differs from mammalian ANP.

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Area of Science:

  • Cardiovascular Physiology
  • Comparative Endocrinology
  • Renal Physiology

Background:

  • Avian hearts possess membrane-bound granules analogous to mammalian atriopeptin (ANP) granules.
  • Previous studies indicated chicken heart extracts cause hypotension but not natriuresis/diuresis, unlike mammalian ANP.

Purpose of the Study:

  • To identify chicken heart regions with hypotensive activity.
  • To evaluate the effects of chicken heart extracts on rat blood pressure, sodium, and water excretion.

Main Methods:

  • Acid extracts from various chicken and rat tissues were prepared.
  • Extracts were injected into anesthetized chickens to measure mean arterial pressure (MAP) and recovery time.
  • The most potent chicken extract was infused into rats to assess natriuretic and diuretic responses.

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Main Results:

  • Chicken left ventricle extract exhibited the most potent hypotensive activity in chickens.
  • Rat atrial extracts induced longer-lasting hypotension than chicken extracts.
  • Chicken left ventricle extract caused mild natriuresis and diuresis in rats, with a weaker hypotensive effect compared to chickens.

Conclusions:

  • The hypotensive substance in chicken hearts, primarily located in the left ventricle, appears distinct from mammalian ANP.
  • Differences in renal and cardiovascular responses suggest a unique avian cardiac peptide.