[Preimplantation genetic diagnosis].

Area of Science:

• Reproductive medicine
• Medical genetics

Background:

• Preimplantation genetic diagnosis (PGD) is publicly available in Denmark for families with a risk of inherited childhood diseases.
• It serves as an alternative to prenatal diagnosis, offering reproductive choices.

Purpose of the Study:

• To describe the outcomes and current practices of PGD in Denmark.
• To compare PGD outcomes with established assisted reproductive technologies.

Main Methods:

• Trophectoderm biopsy followed by vitrification is the current standard strategy.
• Diagnostic testing is performed on biopsied embryos.

Main Results:

• As of 2013, 134 children were born following PGD.
• Clinical pregnancy rates are now comparable to those achieved with in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI).
• Perinatal and neonatal outcomes are similar to those following IVF/ICSI.

Conclusions:

• PGD is a well-established and effective reproductive option in Denmark.
• The technique provides outcomes comparable to standard IVF/ICSI procedures.
• Current PGD strategies ensure successful implantation and healthy offspring.