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Updated: Feb 12, 2026

Fabrication of a Dipole-assisted Solid Phase Extraction Microchip for Trace Metal Analysis in Water Samples
Published on: August 7, 2016
A hybrid monolithic column based on layered double hydroxide-alginate hydrogel for selective solid phase extraction
Jing Wang1, Qingfeng Yang1, Liang Zhang1
1College of Food Science and Engineering, Northwest A&F University, Yangling 712100, Shaanxi, China.
Abstract:
In order to develop an accurate and precise determination method based on solid phase extraction of Pb(II) in food and water samples, a hybrid monolithic column based on layered double hydroxides (LDHs) nanosheets-alginate hydrogel has been synthesized. Combining the advantages of porous 3D framework of hydrogel with selective adsorption of LDHs toward Pb(II), the hydrogel-based hybrid monolithic column shows enhanced enrichment selectivity and efficiency for target ions. Effects of hydrogel composition, pH, concentration and type of eluent, sample volume, and interfering ions on the recoveries of the analytes were also investigated. Under the optimal experiment conditions of method, the limit of detection, preconcentration factor and precision as RSD% are found to be 0.39 μg L-1, 53.7 and 2.65%, respectively. Trace Pb(II) can be quantitatively preconcentrated at pH 6.0 with recoveries >97%. Finally, the method was successfully verified by analyzing spiked Pb2+ in water and drinking samples.
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