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Cardiovascular morbidity and mortality in patients with aortic valve sclerosis: A systematic review and meta-analysis

Matteo Nicola Dario Di Minno1, Alessandro Di Minno2, Pasquale Ambrosino3

  • 1Department of Advanced Biomedical Sciences, Division of Cardiology, Federico II University, Naples, Italy.

International Journal of Cardiology
|April 7, 2018
PubMed

Insights

Aortic valve sclerosis (AVSc) is linked to increased risks of coronary artery disease, stroke, and cardiovascular mortality. Screening for AVSc may improve cardiovascular risk stratification and patient monitoring.

Area of Science:

  • Cardiology
  • Preventive Medicine
  • Geriatrics

Background:

  • Aortic valve sclerosis (AVSc) is a common finding, but its association with cardiovascular (CV) events remains debated.
  • Previous studies have yielded inconsistent results regarding the link between AVSc and adverse CV outcomes.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the association between AVSc and fatal/non-fatal CV and cerebrovascular events.
  • To quantify the risk of coronary artery disease (CAD), stroke, and CV mortality in patients with AVSc.

Main Methods:

  • Systematic literature search of PubMed, Web of Science, Scopus, and EMBASE databases.
  • Inclusion of 31 studies with 10,537 AVSc patients and 25,005 controls.
  • Meta-analysis of Odds Ratios (OR) and attributable risks for CAD, stroke, and CV mortality.

Main Results:

  • AVSc patients had a significantly higher risk of CAD (OR: 2.02), stroke (OR: 1.41), and CV mortality (OR: 2.70) compared to controls.
  • Attributable risks were substantial: 35.8% for CAD, 33.0% for stroke, and 67.7% for CV mortality.
  • Findings were consistent when using multivariate analysis results.

Conclusions:

  • AVSc is significantly associated with increased risks of CAD, stroke, and CV mortality.
  • Patients with AVSc may benefit from intensified CV risk monitoring.
  • AVSc screening could be integrated into cardiovascular risk stratification protocols.
Abstract

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