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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
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Elevated troponin in patients with acute stroke - Is it a true heart attack?

George V Dous1, Angela C Grigos2, Richard Grodman3

  • 1SUNY Downstate, Department of Cardiology, Brooklyn, New York, United States.

The Egyptian Heart Journal : (EHJ) : Official Bulletin of the Egyptian Society of Cardiology
|April 7, 2018
PubMed

Insights

Elevated troponin in acute stroke patients is common due to shared risk factors with ischemic heart disease. This review clarifies the biologic link, diagnostic differences, and prognostic significance of troponin in stroke.

Area of Science:

  • Cardiology
  • Neurology
  • Biochemistry

Background:

  • Ischemic heart disease (IHD) and cerebrovascular disease (CVD) often coexist.
  • Shared risk factors link IHD and CVD.
  • Troponin elevation in acute stroke is a frequent clinical scenario with uncertain prognostic value.

Purpose of the Study:

  • To explore the biologic relationship between acute stroke and elevated troponin.
  • To differentiate the pathophysiology of positive troponin in stroke versus acute myocardial infarction (AMI).
  • To assess the prognostic significance of positive troponin in acute stroke patients.

Main Methods:

  • Literature review of existing studies.
  • Analysis of biologic and pathophysiologic mechanisms.
  • Examination of prognostic data in acute stroke patients.

Main Results:

  • The review identifies the biological links between stroke and troponin elevation.
  • Pathophysiological differences between troponin in stroke and AMI are determined.
  • Prognostic implications of troponin in stroke are evaluated.

Conclusions:

  • Understanding troponin's role in stroke is crucial for patient management.
  • Further research is needed to clarify prognostic significance.
  • Guidance for clinical management based on current data and guidelines is provided.

Keywords:
ACS, acute coronary syndromeAMI, acute myocardial infarctionCAD, Coronary Artery DiseaseCAST, Chinese Acute Stroke TrialCK-MB, Creatine Kinase-MBCT, computed tomographyCVD, Cardiovascular DiseaseDAPT, dual antiplatelet therapyECG, electrocardiogramICH, intracranial hemorrhageIHD, Ischemic Heart DiseaseIST, International Stroke TrialLDL, low-density lipoproteinLV, left ventricularMI, myocardial infarctionMyocardial infarctionNHS, neurogenic heart syndromeNeurogenic heart syndromeSAH, subarachnoid hemorrhageStrokeTIA, Transient Ischemic AttacksTRELAS, The Troponin Elevation in Acute Ischemic StrokeTroponincTnI, Troponin IcTnT, Troponin T

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