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Multifunctional biomedical imaging in physiological and pathological conditions using a NIR-II probe.

Kangquan Shou1,2, Chunrong Qu2,3, Yao Sun2,4

  • 1Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, China.

Advanced Functional Materials
|April 7, 2018
PubMed
Summary

A novel near-infrared II (NIR-II) small molecule dye, CQS1000, encapsulated in vesicles, enables advanced in vivo imaging. This probe offers superior resolution and depth for monitoring circulatory conditions and guiding surgical tumor removal.

Keywords:
NIR-IIfluorescence imagingsentinel lymph nodetumorvascular and lymphatic system

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Area of Science:

  • Biomedical Imaging
  • Nanotechnology
  • Organic Chemistry

Background:

  • Near-infrared II (NIR-II) imaging offers superior resolution and tissue penetration compared to visible and NIR-I regions.
  • Developing novel probes is crucial for advancing in vivo diagnostic and surgical capabilities.
  • Small molecule dyes encapsulated in vesicles show promise for enhanced biocompatibility and imaging performance.

Purpose of the Study:

  • To develop and evaluate a novel small molecule NIR-II dye encapsulated in phospholipid vesicles (CQS1000) for multifunctional in vivo biological imaging.
  • To assess the probe's efficacy in visualizing physiological and pathological conditions of the circulatory system.
  • To determine the probe's utility in guiding surgical procedures like tumor resection and sentinel lymph node biopsy.

Main Methods:

  • Synthesis of a novel small molecule NIR-II dye: 5,5'-(1H,5H-benzo[1,2-c:4,5-c'] bis[1,2,5]thiadiazole)-4,8-diyl)bis(N,N-bis(4-(3-((tert-butyldimethylsilyl)oxy)propyl)phenyl) thiophen-2-amine).
  • Encapsulation of the dye into phospholipid vesicles to create the CQS1000 probe.
  • In vivo studies utilizing the CQS1000 probe for dynamic visualization of circulatory systems and surgical guidance.

Main Results:

  • The CQS1000 probe demonstrated noninvasive, dynamic visualization of lymphatic drainage, tumor angiogenesis, arterial thrombus, and ischemia with high spatial and temporal resolution.
  • The probe exhibited a favorable blood circulation half-life, facilitating precise tumor resection (e.g., osteosarcoma) and accelerated lymph node dissection for sentinel lymph node biopsy.
  • NIR-II imaging with CQS1000 surpassed traditional NIR-I imaging and pathological assessments in clinical diagnosis and treatment guidance.

Conclusions:

  • CQS1000 is a highly promising NIR-II probe for multifunctional biomedical imaging.
  • The probe enables enhanced visualization of physiological and pathological conditions, surpassing existing modalities.
  • CQS1000 holds significant potential for improving clinical diagnosis and guiding surgical interventions.