Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

801
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
801
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.6K
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

3.6K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.6K
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

241
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
241
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

713
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
713
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

264
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
264

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Calprotectin and aMMP-8 as biomarkers in gingival crevicular fluid in geriatric inpatients.

Frontiers in dental medicine·2026
Same author

Impaired healing following implant placement surgery: A case report of a modern-day manifestation of scurvy.

Clinical advances in periodontics·2025
Same author

Association between anemia and vitamin D deficiency in German seniors : A retrospective data analysis.

Zeitschrift fur Gerontologie und Geriatrie·2024
Same author

Oral Health and the Association with Blood Parameters in Neurogeriatric Inpatients without Relevant Systemic Inflammation: An Observational Study.

Geriatrics (Basel, Switzerland)·2024
Same author

[Geriatric assessment in dentistry : A review of chewing function tests].

Zeitschrift fur Gerontologie und Geriatrie·2023
Same author

Impact of an interdisciplinary curriculum for dental students (GeriDent-Cologne) on attitudes and awareness towards older people and geriatric conditions.

European journal of dental education : official journal of the Association for Dental Education in Europe·2021

Related Experiment Video

Updated: Feb 12, 2026

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
09:22

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet

Published on: November 4, 2015

12.6K

[Thromboembolism prophylaxis in old age].

Gabriele Röhrig1, Gerald Kolb2,

  • 1Zentrum für spezialisierte geriatrische Diagnostik, MVZ Medicum Köln-Ost, Johann-Classen-Str. 68, 51103, Köln, Deutschland. gabriele.roehrig-herzog@mvz-koeln-ost.de.

Zeitschrift Fur Gerontologie Und Geriatrie
|April 7, 2018
PubMed
Summary
This summary is machine-generated.

Anticoagulation in older adults is crucial for preventing stroke and deep vein thrombosis, outweighing bleeding risks. Established tools help assess and manage these risks effectively in geriatric patients.

Keywords:
AnticoagulantsAtrial fibrillationBleedingDeep-vein thrombosisEmbolisms

More Related Videos

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans
11:57

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

9.2K
Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast
10:41

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Published on: August 20, 2013

13.3K

Related Experiment Videos

Last Updated: Feb 12, 2026

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
09:22

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet

Published on: November 4, 2015

12.6K
Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans
11:57

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

9.2K
Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast
10:41

Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast

Published on: August 20, 2013

13.3K

Area of Science:

  • Geriatric Medicine
  • Cardiology
  • Hematology

Background:

  • Anticoagulation in geriatric patients presents challenges due to increased bleeding and thromboembolic risks.
  • Comorbidities like renal insufficiency and polymedication significantly impact these risks.
  • Advanced age is a primary risk factor for deep vein thrombosis and atrial fibrillation.

Purpose of the Study:

  • To review the epidemiology of thromboembolic problems in the aged.
  • To discuss current diagnostic and therapeutic strategies for anticoagulation in older adults.
  • To highlight the benefits of anticoagulation in preventing stroke in elderly patients with atrial fibrillation.

Main Methods:

  • Review of epidemiological data on thromboembolic events in the elderly.
  • Analysis of established diagnostic tools for risk assessment.
  • Evaluation of current therapeutic guidelines for anticoagulation in geriatric populations.

Main Results:

  • Older patients, especially those with atrial fibrillation, have a high stroke risk.
  • The benefits of anticoagulation for stroke prevention often outweigh bleeding risks in the very old.
  • Age itself is not a reason to withhold anticoagulation.

Conclusions:

  • Anticoagulation is vital for geriatric patients at risk of thromboembolic events.
  • Risk assessment and management are key to safe and effective anticoagulation in the elderly.
  • Timely anticoagulation significantly improves outcomes by preventing stroke and deep vein thrombosis.